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Asymmetric Synthesis and Reactions of Axially Chiral Amides

轴向手性酰胺的不对称合成与反应

基本信息

批准号：
0135520
负责人：
Dennis Curran
金额：
$ 58万
依托单位：
University of Pittsburgh
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2002
资助国家：
美国
起止时间：
2002-01-01 至 2006-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0135520&HistoricalAwards=false
关键词：
Asymmetric Synthesis Reactions Axially Chiral

项目摘要

The focus of research is the development of synthetic methodology based on the use of axially chiral anilides. New routes for the preparation of anilides will be studied and new reactions that transfer axial chirality from precursor to product will be developed. Radical cyclizations, additions and hydrogen transfer reactions will make up the initial foci of the work. Further, non-radical reactions such as asymmetric organolithium and organopalladium cyclizations will be studied. The research is designed to advance the understanding of the synthesis, structure (including rotational behavior) and reactions of axially chiral amides in order to expand the synthetic utility of this class of compounds.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Dennis P. Curran of the Department of Chemistry at the University of Pittsburgh. Professor Curran will focus his work on developing methodology for the transfer of chirality of synthetic precursors to new stereocenters in products. The work represents a broad-based study of the structural features and synthetic potential of a novel class of chiral anilides. The methodology has fundamental importance and could lead to the production of novel catalysts, reagents and synthetic intermediates of use to synthetic chemists and, beyond that, to the pharmaceutical industry. The research also provides an appropriate venue for the training of students at the graduate level.

研究的重点是开发基于使用轴向手性苯胺的合成方法。将研究制备苯胺的新路线，并开发将轴向手性从前体转移到产物的新反应。自由基环化反应、加成反应和氢转移反应将构成本工作的初始焦点。此外，非自由基反应，如不对称的有机锂和有机钯环化将进行研究。该研究旨在促进对轴向手性酰胺的合成，结构（包括旋转行为）和反应的理解，以扩大这类化合物的合成效用。通过这一更新奖项，有机和大分子化学计划支持匹兹堡大学化学系的Dennis P. Curran博士的研究。 Curran教授将专注于开发将合成前体的手性转移到产品中新立体中心的方法。这项工作代表了一个广泛的研究的结构特点和合成潜力的一类新的手性苯胺。该方法具有根本的重要性，并可能导致生产新的催化剂，试剂和合成中间体的合成化学家使用，除此之外，制药工业。这项研究还为研究生一级的学生培训提供了一个适当的场所。