Asymmetric Synthesis and Reactions of Axially Chiral Amides

研究的重点是基于轴向手性苯胺的合成方法学的发展。将研究制备苯胺的新路线，开发将轴向手性从前驱体转移到产物的新反应。自由基环化反应、加成反应和氢转移反应将构成这项工作的最初焦点。此外，还将研究非自由基反应，如不对称有机锂和有机钯的环化反应。这项研究旨在促进对轴向手性酰胺的合成、结构(包括旋转行为)和反应的了解，以扩大这类化合物的合成用途。通过这次更新奖，有机和高分子化学计划支持匹兹堡大学化学系的Dennis P.Curran博士的研究。柯伦教授将专注于开发将合成前体的手性转移到产品中新的立体中心的方法学。这项工作代表了对一类新型手性苯胺的结构特征和合成潜力的广泛研究。该方法具有根本的重要性，并可能导致合成化学家使用的新型催化剂、试剂和合成中间体的生产，除此之外，还可能导致制药行业的生产。这项研究也为研究生水平的培训提供了一个合适的场所。

The focus of research is the development of synthetic methodology based on the use of axially chiral anilides. New routes for the preparation of anilides will be studied and new reactions that transfer axial chirality from precursor to product will be developed. Radical cyclizations, additions and hydrogen transfer reactions will make up the initial foci of the work. Further, non-radical reactions such as asymmetric organolithium and organopalladium cyclizations will be studied. The research is designed to advance the understanding of the synthesis, structure (including rotational behavior) and reactions of axially chiral amides in order to expand the synthetic utility of this class of compounds.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Dennis P. Curran of the Department of Chemistry at the University of Pittsburgh. Professor Curran will focus his work on developing methodology for the transfer of chirality of synthetic precursors to new stereocenters in products. The work represents a broad-based study of the structural features and synthetic potential of a novel class of chiral anilides. The methodology has fundamental importance and could lead to the production of novel catalysts, reagents and synthetic intermediates of use to synthetic chemists and, beyond that, to the pharmaceutical industry. The research also provides an appropriate venue for the training of students at the graduate level.