Effective New Methods For Synthesis of Chiral Molecules

这项研究的重点是双重的。首先，稳态立体选择是一种概念上的新方法，其中反应拓扑决定立体化学结果，将用于开发新的合成方法。其次，采用前手性助剂制备手性苯胺。由美日计划提供的国际组成部分加强了拟议的研究。通过这一基于成就的更新奖，有机和大分子化学计划和美日合作研究计划正在支持匹兹堡大学化学系的丹尼斯·p·柯伦博士的研究。柯伦教授将专注于发展有机反应中的立体选择。在合成过程中控制立体化学的能力在有机化学学科内外以及在诸如药品生产等领域都具有根本的重要性。美日合作计划促进的合作将增加拟议工作的潜力。

The foci of this research are twofold. First, stereoselection at the steady state, a conceptually new method wherein reaction topology dictates stereochemical outcome, will be used to develop new synthetic methodology. Second, a prochiral auxiliary approach will be used to produce chiral anilides. An international component provided by the US-Japan Program enhances the proposed research.With this Accomplishment-Based renewal award, the Organic and Macromolecular Chemistry Program and the U.S.- Japan Cooperative Research Program are supporting the research of Dr. Dennis P. Curran of the Department of Chemistry at the University of Pittsburgh. Professor Curran will focus his work on developing stereoselection in organic reactions. The ability to control stereochemistry in synthesis is of fundamental importance in and beyond the discipline of organic chemistry and into such areas as the production of pharmaceuticals. A collaboration fostered by the US-Japan Program will increase the potential of the proposed work.