New Synthetic Organic Reactions

本项目主要研究轴向手性酰胺类化合物的合成应用。更好地理解含有单一邻位取代基的轴向手性苯胺的结构特征对氮-芳香族旋转势垒的影响。新的自由基易位，然后是自由基加成或环化，具有轴向和螺旋手性的潜在转移，将被研究。还将研究轴向手性苯胺的离子反应和有机金属反应。此外，还将探索轴向手性酰胺的自由基反应、α-卤代胺的5-内环化、与O2的氧化重芳化反应。通过这个奖项，有机和高分子化学项目支持匹兹堡大学化学系教授丹尼斯·P·柯伦的研究。柯伦教授的研究工作围绕轴向手性酰胺及其合成应用展开。该项目对化工和制药行业具有相当重要的意义，因为它可能会影响有机分子的制备方式。

This project is focused on the synthetic applications of axially chiral amides. A better understanding of the structural features effecting nitrogen-aromatic rotation barriers of axially chiral anilides bearing a single ortho-substituent will be developed. New radical translocations followed by radical addition or cyclization with potential transfer of both axial and helical chirality will be investigated. Ionic and organometallic reactions of axially chiral anilides will also be studied. In addition, radical reactions of axially chiral amides, 5-endo cyclizations of alpha-haloenamides, oxidative rearomatizations with O2 will be explored. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Dennis P. Curran of the Department of Chemistry at University of Pittsburgh. Professor Curran's research efforts revolve around axially chiral amides and their synthetic applications. The project is of considerable significance to the chemical and pharmaceutical industry, as it could impact how organic molecules are prepared.