New Synthetic Organic Reactions

新的有机合成反应

• 批准号: 0645998
• 负责人: Dennis Curran
• 金额: $ 48.9万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645998&HistoricalAwards=false
• 关键词: New; Synthetic; Organic; Reactions

This project is focused on the synthetic applications of axially chiral amides. A better understanding of the structural features effecting nitrogen-aromatic rotation barriers of axially chiral anilides bearing a single ortho-substituent will be developed. New radical translocations followed by radical addition or cyclization with potential transfer of both axial and helical chirality will be investigated. Ionic and organometallic reactions of axially chiral anilides will also be studied. In addition, radical reactions of axially chiral amides, 5-endo cyclizations of alpha-haloenamides, oxidative rearomatizations with O2 will be explored. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Dennis P. Curran of the Department of Chemistry at University of Pittsburgh. Professor Curran's research efforts revolve around axially chiral amides and their synthetic applications. The project is of considerable significance to the chemical and pharmaceutical industry, as it could impact how organic molecules are prepared.

本项目主要研究轴向手性酰胺类化合物的合成应用。 更好地理解的结构特征影响氮芳香旋转障碍的轴向手性苯胺轴承一个单一的邻位取代基将发展。 新的自由基易位，然后自由基加成或环化与潜在的轴向和螺旋手性转移将进行研究。 轴向手性苯胺的离子和有机金属反应也将被研究。 此外，轴向手性酰胺的自由基反应，α-卤代酰胺的5-内环化反应，O2氧化重排反应也将被探索。 有了这个奖项，有机和高分子化学计划正在支持匹兹堡大学化学系的Dennis P. Curran教授的研究。 Curran教授的研究工作围绕轴向手性酰胺及其合成应用。 该项目对化学和制药行业具有相当重要的意义，因为它可能影响有机分子的制备方式。