Purchase of X-ray Diffractometer and Computer System

这份来自化学研究仪器项目的合同将帮助宾夕法尼亚大学化学系购买x射线衍射仪和相关的数据收集和分析系统，并升级旧的x射线衍射仪。该仪器将极大地促进以下领域的研究：1)有机硅化合物的过渡金属配合物；新结构与催化剂，2)烷基硅烷与碳硅烷催化脱氢偶联，3)天然产物结构测定、合成与有机光化学；新型抗肿瘤药物Hitachimycin（又名Stubomycin）； 4)生物有机化学：非肽类肽；5)材料化学与无机催化；硼基陶瓷的新聚合物前驱体，6)铁电金属-氧聚合物和金属-氧聚合物中的金属-绝缘体跃迁，7)金属大环配合物的有机金属反应性，8)抗肿瘤化合物的合成策略。x射线衍射仪用于对分子的完整三维结构进行精确的测量。得到的信息给出了给定分子的所有键距和键角的精确值，并给出了该分子相对于邻近分子的空间排列的准确信息。

This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at the University of Pennsylvania in the purchase of an x-ray diffractometer and associated data collection and analysis system and an upgrade of an older x-ray diffractometer. This new instrument will enhance greatly research in a number of areas including the following: 1) Transition metal complexes of organosilicon compounds: New structures and catalysts, 2) Catalytic dehydrogenative coupling of alkylsilanes to carbosilanes, 3) Natural product structure determination, synthesis and organic photochemistry: Hitachimycin (a.k.a. Stubomycin), a novel antitumor agent, 4) Bioorganic chemistry: Non-peptidal peptidomimetics, 5) Materials chemistry and inorganic catalysis: New polymeric precursors to boron-based ceramics, 6) Ferroelectric metal-oxo polymers and metal-insulator transitions in metal-oxo polymers, 7) Organometallic reactivity of metallomacrocyclic complexes, 8) Strategies for synthesis of anti-tumor compounds. %%% The x-ray diffractometer is used to make accurate and precise measurements of the full three-dimensional structure of a molecule. The information obtained gives the precise values of all the bond distances and bond angles of a given molecule and it gives accurate information about the spatial arrangement of that molecule relative to the neighboring molecules.