Purchase of a 400 MHz NMR Spectrometer

化学研究仪器和设施计划的这一奖项将帮助加州大学圣巴巴拉分校的化学系购买400 MHz核磁共振光谱仪。这项研究将极大地促进以下领域的研究：设计和合成可作为核酸水解的序列特异性催化剂的分子；超结构卟啉的制备；用于非对映选择性和对映选择性还原的试剂的开发；有机铜化学的研究；有机金属化学中新合成方法的开发；Diels-Alder反应的探索；二基氢提取反应的研究，包括这类物种与核酸的序列特异性反应；取代富勒烯的有机化学的发展；以及具有特殊化学和物理性质的有机聚合物的制备和研究。核磁共振(核磁共振)光谱仪被用来获得关于分子结构(存在什么类型的碳和/或氢原子和/或杂原子，每种类型的原子的相对数量以及它们在分子中如何相互连接)和分子动力学(分子的各个部分移动的速度有多快)的信息。该仪器对于任何有意义的现代合成化学研究项目都是必不可少的。

This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at the University of California--Santa Barbara in the purchase of a 400 MHz NMR spectrometer. This acquisition will enhance greatly the research in a number of areas including the following: the design and synthesis of molecules which can function as sequence-specific catalysts of nucleic acid hydrolysis, the preparation of superstructural porphyrins, the development of reagents for diastereoselective and enantioselective reductions, studies of organocopper chemistry, the development of new synthetic methods in organometallic chemistry, explorations of the Diels-Alder reaction, studies of diyl hydrogen abstraction reactions including sequence-specific reactions of such species with nucleic acids, development of the organic chemistry of substituted fullerenes, and the preparation and study of organic polymers with unusual chemical and physical properties. A nuclear magnetic resonance (NMR) spectrometer is used to obtain information about molecular structure (what types of carbon and/or hydrogen atoms and/or hetero-atoms are present, what are the relative number of each type of atoms and how are they connected to one another in the molecule) and molecular dynamics (how rapidly are the various parts of the molecule moving). This instrument is essential for any meaningful, modern synthetic chemistry research program.