Purchase of 600 MHz High Resolution NMR

购买 600 MHz 高分辨率 NMR

• 批准号: 9400226
• 负责人: Robert Pecora
• 金额: $ 50万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-15 至 1995-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9400226&HistoricalAwards=false
• 关键词: Purchase; 600; MHz; Resolution; NMR

This award from the Chemistry Research Instrumentation Facilities Program will help the Department of Chemistry at Stanford University acquire a 500 MHz NMR spectrometer and solid state accessories to be used to upgrade the existing 400 MHz NMR spectrometer which will be used in research. The research activities to be supported include: (1) studies on the molecular basis of carcinogenesis, solution structures of peptide receptors, the synthesis and mode of action of DNA cleaving agents, the synthesis of taxol analogues and studies on their mode of action, mechanistic and synthetic organometallic chemistry, and mechanistic and synthetic photochemistry, (2) stereochemistry and mechanism of organometallic reactions in polymer synthesis and catalysis, (3) new approaches for synthetic efficiency, (4) mechanistic enzymology of oxidosqualene cyclization, (5) Coenzyme A Analogs as Probes of Enzymatic Reaction Mechanisms, and (6) Theoretical and Computational X-ray Absorption Spectroscopy. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers and catalysis, and in biology.

这项来自化学研究仪器设施计划的奖项将帮助斯坦福大学化学系购买一台 500 MHz NMR 波谱仪和固态配件，用于升级现有的用于研究的 400 MHz NMR 波谱仪。 资助的研究活动包括：（1）致癌的分子基础、肽受体的溶液结构、DNA切割剂的合成和作用方式、紫杉醇类似物的合成及其作用方式研究、机理和合成有机金属化学、机理和合成光化学等研究；（2）聚合物中有机金属反应的立体化学和机理研究 合成和催化，(3) 合成效率的新方法，(4) 氧化角鲨烯环化的机械酶学，(5) 辅酶 A 类似物作为酶反应机制的探针，以及 (6) 理论和计算 X 射线吸收光谱。 核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具。 它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，获得最先进的核磁共振波谱分析至关重要。 这些核磁共振研究的结果在聚合物和催化以及生物学等领域非常有用。