Purchase of 600 MHz High Resolution NMR

这份来自化学研究仪器设备项目的合同将帮助斯坦福大学化学系获得一台500 MHz核磁共振光谱仪和固态附件，用于升级现有的400 MHz核磁共振光谱仪，该光谱仪将用于研究。资助的研究活动包括：(1)致癌的分子基础、肽受体的溶液结构、DNA切割剂的合成和作用方式、紫杉醇类似物的合成及其作用方式、有机金属化学的机理和合成、光化学的机理和合成；(2)聚合物合成和催化中有机金属反应的立体化学和机理；(3)合成效率的新途径；(4)氧化角鲨烯环化的机制酶学；(5)辅酶A类似物作为酶反应机理的探针；(6)理论和计算x射线吸收光谱。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱是必不可少的化学家谁正在进行前沿研究。从这些核磁共振研究的结果是有用的领域，如聚合物和催化，并在生物学。

This award from the Chemistry Research Instrumentation Facilities Program will help the Department of Chemistry at Stanford University acquire a 500 MHz NMR spectrometer and solid state accessories to be used to upgrade the existing 400 MHz NMR spectrometer which will be used in research. The research activities to be supported include: (1) studies on the molecular basis of carcinogenesis, solution structures of peptide receptors, the synthesis and mode of action of DNA cleaving agents, the synthesis of taxol analogues and studies on their mode of action, mechanistic and synthetic organometallic chemistry, and mechanistic and synthetic photochemistry, (2) stereochemistry and mechanism of organometallic reactions in polymer synthesis and catalysis, (3) new approaches for synthetic efficiency, (4) mechanistic enzymology of oxidosqualene cyclization, (5) Coenzyme A Analogs as Probes of Enzymatic Reaction Mechanisms, and (6) Theoretical and Computational X-ray Absorption Spectroscopy. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers and catalysis, and in biology.