Catalysts with D2 Symmetry for Asymmetric Cyclopropanations by Vinylcarbenoids

戴维斯这项研究集中在使用具有D2对称性的Rh(II)催化剂与乙烯基卡宾进行不对称的环丙烷化反应。这项工作将评估一系列潜在的催化剂，并将应用于合成手性环丙烷氨基酸、核苷衍生物和一类新的倍半萜类化合物。此外，还将阐明导致Rh(II)羧酸盐诱导手性的因素。有了这个奖项，合成有机计划将支持维克森林大学化学系的Huw M.L.Davies博士的研究。戴维斯教授的工作将集中在使用Rh(II)催化剂来实现光学活性环丙烷衍生物的合成。

DAVIES This research is centered on the use of rhodium(II) catalysts with D2 symmetry for enantioselective cyclopropanation with vinylcarbenoids. The work will evaluate a range of potential catalysts and will be applied to the synthesis of chiral cyclopropane amino acids, nucleoside derivatives and a new class of sesquiterpenes called tremulanes. The factors leading to chiral induction by rhodium(II) carboxylates will also be elucidated.With this award, the Synthetic Organic Program is supporting the research of Dr. Huw M. L. Davies of the Department of Chemistry at wake Forest University. Professor Davies will focus his work on the use of rhodium(II) catalysts to achieve the the synthesis of optically active cyclopropane derivatives.