Expanding the Scope of Donor/Acceptor Carbenoids

有了这个奖项，化学合成计划是支持教授Huw M的基础研究。L.戴维斯在埃默里大学。Davies教授和他的学生将利用手性催化剂来开发有机合成中的新的对映选择性方法。 该研究探讨了由金属稳定的乙烯基卡宾的乙烯基化反应引起的反应，并有可能以对映选择性的方式产生全新的转化。乙烯基卡宾的乙烯基化反应还没有得到很好的理解，这些研究有望有助于铑卡宾化学的基本理解。Davies教授将把这个项目的研究和教育部分整合到几个新的项目中，为学术研究人员建立一个合作和支持的环境。一个新的化学研究多样性计划，将带来来自少数民族大学的教授与他们的学生2暑期研究项目的工作。 一个强大的学生辅导计划已被设计，以确保学生成为专家在他们的研究的特定领域，并开发的经验和沟通技巧的广度必要在他们未来的职业生涯中非常有效。戴维斯教授已经开发了许多推广活动提供给他的学生，如斯佩尔曼杂志俱乐部，科学咖啡馆，亚特兰大科学节，化学创新讲座系列，视频会议短期课程，并通过访问工业演讲者的职业发展讲座。在这项研究中，金属乙烯基卡宾的合成转化，进行初始反应发生在乙烯基卡宾的乙烯基位置，将进行探索。将开发的方法来控制金属乙烯基卡宾的反应性的网站，通过使用金催化剂或空间体积庞大的铑催化剂。一些新的立体选择性有限的优先协议将被检查，包括[4+3]环加成，[4+2]环加成和crotylations，这将开辟新的可能性，快速构建复杂的目标分子。

With this award, the Chemical Synthesis program is supporting fundamental research of Professor Huw M. L. Davies at Emory University. Professor Davies and his students will employ chiral catalysts for the development of new enantioselective methods in organic synthesis. The study explores reactions induced by vinylogous reactions of metal-stabilized vinylcarbenes and has the potential of generating entirely new transformations in an enantioselective manner. The vinylogous reactions of vinylcarbenes are not yet well understood and these studies are expected to contribute to the fundamental understanding of rhodium carbene chemistry. Professor Davies will integrate the research and educational components of this project within several new initiatives for developing a collaborative and supportive environment for academic researchers. A new Chemistry Research & Diversity Program is planned which will bring professors from minority universities with 2 of their students to work on summer research projects. A robust student-mentoring plan has been designed to ensure the students become experts in their specific area of research and develop the breadth of experience and the communication skills necessary to be highly effective in their future careers. Professor Davies has developed many outreach activities available to his students such as the Spelman Journal Club, science cafes, the Atlanta Science Festival, Chemical Innovator Lecture Series, videoconference short courses, and career development lectures by visiting industrial speakers. In this research, synthetic transformations of metal vinylcarbenes, proceeding by an initial reaction occurring at the vinylogous position of the vinylcarbene, will be explored. Methods will be developed to control the site of reactivity of the metal vinylcarbenes by using either gold catalysts or sterically bulky dirhodium catalysts. A number of novel stereoselective protocols of limited prior precedence will be examined, including [4+3] cycloadditions, [4+2] cycloadditions and crotylations, which will open up new possibilities for the rapid construction of complex target molecules.