D2 Symmetric Catalysts in Asymmetric Synthesis

本研究的重点是通过控制简单的手性配体在络合物中的排列来制备D2对称催化剂，而不是设计复杂的D2对称配体。这些催化剂将在不对称环丙烷化、氮杂环化和环氧化反应中进行评价。使用乙烯基卡宾和富电子烯烃的分子间C-H插入和3+2环将被详细研究。通过这个续展奖项，有机化学和高分子化学计划支持纽约州立大学布法罗分校化学系的休·M·L·戴维斯博士的研究。戴维斯教授将专注于设计金属催化的不对称转化。该方法和得到的手性产物有可能用于制备具有有趣生物学特性的分子。

The focus of this research is the preparation of D2 symmetric catalysts by control of the arrangement of simple chiral ligands within a complex rather than designing elaborate ligands of D2 symmetry. The catalysts will be evaluated in asymmetric cyclopropanations, aziridinations and epoxidations. Intermolecular C-H insertions and 3 + 2 annulations using vinylcarbenoids and electron rich alkenes will be studied in detail. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M. L. Davies of the Department of Chemistry at SUNY-Buffalo. Professor Davies will focus his work on designing metal catalyzed asymmetric transformations. The methodology and the resulting chiral products have potential for use in the preparation of molecules with interesting biological properties.