Catalytic Asymmetric Intermolecular C-H Activation

本研究的重点是通过扩大可以纳入供体/受体取代的类碳化合物的供体基团的范围来优化和扩大不对称碳氢插入化学的范围。首先，乙烯基重氮乙酸酯将用作类碳前体，随后对乙烯基进行改性。其次，将开发原位生成类碳前体的方法。第三，将探索碳氢键插入/Cope重排的组合。通过这个奖项，有机和大分子化学项目支持了纽约州立大学布法罗分校化学系的Huw M.L Davies博士的研究。戴维斯博士将专注于开发金属催化不对称转化的方法。使用供体/受体取代的类碳化合物来增加碳氢插入化学的范围将是本研究的重点。该项目对制药和精细化工行业具有潜在的更广泛的影响，并为本科生、研究生和博士后的培训提供了一个极好的场所。

The focus of this research is to optimize and expand the scope of asymmetric C-H insertion chemistry by expanding the range donor groups that can be incorporated into donor/acceptor-substituted carbenoids. First, vinyldiazoacetates will be used as the carbenoid precursor with subsequent modification of the vinyl group. Second, methods for in situ generation of carbenoid precursors will be developed. Third, a combined C-H insertion/Cope rearrangement will be explored.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M.L Davies of the Department of Chemistry at SUNY at Buffalo. Dr. Davies will focus his work on the development of methodologies for metal catalyzed asymmetric transformations. The use of donor/acceptor-substituted carbenoids to increase the scope of C-H insertion chemistry will be highlighted by this research. The project has potential broader impact for the pharmaceutical and fine chemicals industries and the work provides an excellent venue for the training of undergraduates, graduate students and postdoctoral associates.