Catalytic Asymmetric Intermolecular C-H Activation

本研究的重点是通过扩大供体基团的范围来优化和扩大不对称C-H插入化学的范围，这些基团可以并入到供体/受体取代的卡宾中。首先，乙烯基重氮乙酸酯将被用作类卡宾的前体，随后对乙烯基团进行修饰。第二，将开发原位生成类卡宾前体的方法。第三，将探索C-H插入/COPE重排的组合。凭借这一奖项，有机和高分子化学计划支持纽约州立大学布法罗分校化学系的休·M.L·戴维斯博士的研究。戴维斯博士将把工作重点放在开发金属催化的不对称转化方法上。这项研究将强调使用给体/受体取代的卡宾来扩大C-H插入化学的范围。该项目可能对制药和精细化工行业产生更广泛的影响，该工作为本科生、研究生和博士后助理的培训提供了一个极好的场所。

The focus of this research is to optimize and expand the scope of asymmetric C-H insertion chemistry by expanding the range donor groups that can be incorporated into donor/acceptor-substituted carbenoids. First, vinyldiazoacetates will be used as the carbenoid precursor with subsequent modification of the vinyl group. Second, methods for in situ generation of carbenoid precursors will be developed. Third, a combined C-H insertion/Cope rearrangement will be explored.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M.L Davies of the Department of Chemistry at SUNY at Buffalo. Dr. Davies will focus his work on the development of methodologies for metal catalyzed asymmetric transformations. The use of donor/acceptor-substituted carbenoids to increase the scope of C-H insertion chemistry will be highlighted by this research. The project has potential broader impact for the pharmaceutical and fine chemicals industries and the work provides an excellent venue for the training of undergraduates, graduate students and postdoctoral associates.