Catalytic Asymmetric Intermolecular C-H Activation

催化不对称分子间 C-H 活化

• 批准号: 0350536
• 负责人: Huw Davies
• 金额: $ 56万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0350536&HistoricalAwards=false
• 关键词: Catalytic; Asymmetric; Intermolecular; Activation

The focus of this research is to optimize and expand the scope of asymmetric C-H insertion chemistry by expanding the range donor groups that can be incorporated into donor/acceptor-substituted carbenoids. First, vinyldiazoacetates will be used as the carbenoid precursor with subsequent modification of the vinyl group. Second, methods for in situ generation of carbenoid precursors will be developed. Third, a combined C-H insertion/Cope rearrangement will be explored.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M.L Davies of the Department of Chemistry at SUNY at Buffalo. Dr. Davies will focus his work on the development of methodologies for metal catalyzed asymmetric transformations. The use of donor/acceptor-substituted carbenoids to increase the scope of C-H insertion chemistry will be highlighted by this research. The project has potential broader impact for the pharmaceutical and fine chemicals industries and the work provides an excellent venue for the training of undergraduates, graduate students and postdoctoral associates.

本研究的重点是优化和扩大不对称C-H插入化学的范围，通过扩大范围的供体基团，可以纳入供体/受体取代的类卡宾。 首先，重氮乙酸乙烯酯将用作类卡宾前体，随后对乙烯基进行改性。 其次，将开发原位生成类卡宾前体的方法。 第三，将探索C-H插入/科普重排的组合。有了这个奖项，有机和大分子化学计划将支持布法罗纽约州立大学化学系Huw M.L Davies博士的研究。 Davies博士将专注于金属催化不对称转化方法学的发展。 本研究将强调使用供体/受体取代的类卡宾来增加C-H插入化学的范围。 该项目对制药和精细化工行业具有潜在的更广泛的影响，并为本科生，研究生和博士后助理的培训提供了一个很好的场所。