CCI Center in Selective C-H Functionalization

CCI 选择性 C-H 功能化中心

• 批准号: 1205646
• 负责人: Huw Davies
• 金额: $ 2000万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1205646&HistoricalAwards=false
• 关键词: CCI; Center; Selective; Functionalization

The Center for Selective C-H Functionalization (CCHF) will develop new reactions and synthetic methodologies for activating and functionalizing carbon-hydrogen bonds. The carbon-hydrogen bond has traditionally been considered inert, but recent advances have shown that this bond can be productively exploited. A multi-faceted research team will build the mechanistic understanding required for the development of next-generation, selective catalysts and will develop predictive models for determining site selectivity in complex target synthesis. New catalysts systems and new methods for C-H modification will be challenged and refined in the context of natural product synthesis, library preparation and drug discovery, and materials preparation. Selective C-H bond functionalization will also be extensively investigated and further evolved for the single-step tailoring of the structure and physical properties of known molecules.The field of C-H functionalization is projected to impact the fine chemicals industry, with the potential of revolutionizing synthetic strategies targeting pharmaceuticals and materials. By collaboration and partnership with industry leaders and other major research centers, CCHF will ensure the translation of discoveries in basic research to commercial innovations. A Center-wide commitment to continuing educating of the chemical community on the synthetic potential of this new chemistry will facilitate the development of innovations that lie beyond the scope of the proposed research. The Center also will take an active role in reaching out beyond the chemistry community to engage young students, the public, and underrepresented audiences in developing an understanding of and appreciation for the chemical sciences. Through a novel "Chemistry Communications" program, CCHF will educate and train their scientists on the best practices in communicating science to different audiences. Products generated by this program such as blogs, science animations, and science journalism will serve to educate different audiences (general public, high school teachers, K-12 students) about CCHF's research discoveries, placing the Center in a unique position to make a positive impact on the perception of chemistry in the Nation and the inclusion of more diversity in people pursuing careers in chemistry. Course development, research opportunities, and research partnerships will further enhance the influence that the Center will have on the engagement of students and underrepresented minorities.The Center for Selective C-H Functionalization is funded as part of the Centers for Chemical Innovation (CCI) program.

选择性C-H官能化中心（CCHF）将开发新的反应和合成方法，用于活化和官能化碳-氢键。碳氢键传统上被认为是惰性的，但最近的进展表明，这种键可以被有效地利用。 一个多方面的研究团队将建立下一代选择性催化剂开发所需的机理理解，并将开发用于确定复杂目标合成中的位点选择性的预测模型。新的催化剂体系和新的C-H修饰方法将在天然产物合成，库制备和药物发现以及材料制备的背景下受到挑战和改进。选择性C-H键官能化也将被广泛研究和进一步发展，用于已知分子结构和物理性质的单步定制。C-H官能化领域预计将影响精细化学品行业，具有革命性的针对药物和材料的合成策略的潜力。通过与行业领导者和其他主要研究中心的合作和伙伴关系，CCHF将确保将基础研究中的发现转化为商业创新。整个中心致力于继续教育化学界了解这种新化学的合成潜力，这将促进超出拟议研究范围的创新的开发。该中心还将发挥积极作用，超越化学界，吸引年轻学生，公众和代表性不足的观众，培养对化学科学的理解和欣赏。通过一个新的“化学通信”计划，CCHF将教育和培训他们的科学家在传播科学的最佳实践，以不同的观众。该计划产生的产品，如博客，科学动画和科学新闻将有助于教育不同的受众（公众，高中教师，K-12学生）关于CCHF的研究发现，使该中心处于独特的地位，对国家的化学观念产生积极影响，并将更多的多样性纳入追求化学职业的人中。课程开发，研究机会和研究合作伙伴关系将进一步增强该中心对学生和代表性不足的少数民族参与的影响力。选择性C-H官能化中心是化学创新中心（CCI）计划的一部分。