Integration of FT-NMR Instrument in the Undergraduate Curriculum

9451761埃里亚森购买FT-核磁共振光谱仪将显著改进化学课程。新仪器将使学生能够亲自记录他们自己的光谱，这在教学上优于单纯的书本指导，实践体验一直是我们系的重要目标。这项建议的目标是在二年级的有机化学课程早期介绍基本的1H，13C，DEPT，1H-1H COSY和1H-13C COSY技术。这将有助于调整第二和第三年的实验室课程，以提供实验，使所有学生都参与到以研究为导向的体验中。实验室的学生将被组织成研究小组。该团队将被给予一个实验，将讨论实验设计和程序，将收集和审查数据，并将得出结论并根据需要设计新的实验。与实验室课程是纯研究项目的其他项目不同，我们的计划是提供标准实验和开放式实验的混合。我们的目标是提供一种研究型的氛围，同时提供一个让学生体验切实成功的环境，从而提供发现的兴奋，以吸引学生进入我们的本科生研究计划。这一建议将对有机学、生物物理学、生物化学和物理化学的实验课程产生重大影响。使用1H-1H COSY作为教学工具，有助于提高1H核磁共振基础理论的教学效果。一维和二维核磁共振技术解决结构问题的能力将在有机定性分析和生物化学中得到展示。在我们努力修改我们的基础实验室课程的同时，我们建议正式让学生参与到一个结构化的研究项目中来。将组成由两个或更多教员组成的项目团队，以开发跨学科的项目，而不是由一个教员与一个学生一起工作。将特别努力招收生物/化学双重专业的学生，这些学生往往不参与研究，以增加他们的参与。

9451761 Eliason The acquisition of an FT-NMR spectrometer will significantly improve the chemistry curriculum. The new instrument will give the students the hands-on ability to record their own spectra which is pedagogically superior to book instruction alone, and a hands-on experience has always been an important objective for our department. A goal of this proposal is to introduce basic 1H, 13C, DEPT, 1H- 1H COSY and 1H-13C COSY techniques early in the sophomore organic chemistry course. This will assist in restructuring the laboratory curriculum of the second and third years to provide experiments that engage all students in a research oriented experience. Laboratory students will be organized into research like teams. The team will be given an experiment, will discuss experimental design and procedures, will collect and review data, and will draw conclusions and design new experiments as necessary. Unlike other programs in which the laboratory curriculum is a pure research project, our plan is to provide a mixture of standard and open ended experiments. Our goal is to provide a research type atmosphere while at the same time providing an environment in which the student experiences tangible success thereby providing the excitement of discovery to attract students into our undergraduate research program. The laboratory curriculum of organic, biophysical, biochemistry and physical chemistry will be heavily impacted by this proposal. The effectiveness of teaching of the basic theory of 1H NMR will be aided with the use of 1H- 1H COSY as a teaching tool. The power of 1-D and 2-D NMR techniques to solve structural problems will be shown both in organic qualitative analysis and in biochemistry. Concurrent with our efforts to revise our basic laboratory curriculum we propose to formalize the involvement of students in a structured research program. Instead of a single faculty member working with a single student, project teams consisting of two or more faculty will be formed to develop cross discipline projects. A special effort to recruit dual biology/chemistry major students, who have tended not to be involved in research, will be made to increase their participation.