Integration of FT-NMR Instrument in the Undergraduate Curriculum

9451761 Eliason购买FT-NMR光谱仪将显著改善化学课程。新仪器将使学生能够亲自动手记录自己的光谱，这在教学上上级单纯的书本教学，实践经验一直是我们部门的重要目标。本建议的一个目标是在大二有机化学课程的早期介绍基本的1H，13 C，DEPT，1H- 1H COSY和1H-13 C COSY技术。这将有助于重组第二年和第三年的实验室课程，以提供实验，让所有学生参与以研究为导向的经验。实验室的学生将被组织成像团队一样的研究。该小组将进行一项实验，讨论实验设计和程序，收集和审查数据，并得出结论，并在必要时设计新的实验。不像其他程序中的实验室课程是一个纯粹的研究项目，我们的计划是提供标准和开放式实验的混合物。我们的目标是提供一个研究型的氛围，同时提供一个环境，使学生体验切实的成功，从而提供发现的兴奋，吸引学生进入我们的本科研究计划。 有机，生物物理，生物化学和物理化学的实验室课程将受到严重影响。 将~ 1H-~ 1HCOSY作为一种教学工具，有助于提高~ 1H NMR基础理论的教学效果。1-D和2-D NMR技术解决结构问题的能力将在有机定性分析和生物化学中显示出来。 同时，我们努力修改我们的基本实验室课程，我们建议正式参与学生在一个结构化的研究计划。而不是一个单一的教师与一个学生一起工作，项目团队组成的两个或两个以上的教师将形成开发跨学科项目。 将特别努力招收生物/化学双专业学生，他们往往不参与研究，以增加他们的参与。

9451761 Eliason The acquisition of an FT-NMR spectrometer will significantly improve the chemistry curriculum. The new instrument will give the students the hands-on ability to record their own spectra which is pedagogically superior to book instruction alone, and a hands-on experience has always been an important objective for our department. A goal of this proposal is to introduce basic 1H, 13C, DEPT, 1H- 1H COSY and 1H-13C COSY techniques early in the sophomore organic chemistry course. This will assist in restructuring the laboratory curriculum of the second and third years to provide experiments that engage all students in a research oriented experience. Laboratory students will be organized into research like teams. The team will be given an experiment, will discuss experimental design and procedures, will collect and review data, and will draw conclusions and design new experiments as necessary. Unlike other programs in which the laboratory curriculum is a pure research project, our plan is to provide a mixture of standard and open ended experiments. Our goal is to provide a research type atmosphere while at the same time providing an environment in which the student experiences tangible success thereby providing the excitement of discovery to attract students into our undergraduate research program. The laboratory curriculum of organic, biophysical, biochemistry and physical chemistry will be heavily impacted by this proposal. The effectiveness of teaching of the basic theory of 1H NMR will be aided with the use of 1H- 1H COSY as a teaching tool. The power of 1-D and 2-D NMR techniques to solve structural problems will be shown both in organic qualitative analysis and in biochemistry. Concurrent with our efforts to revise our basic laboratory curriculum we propose to formalize the involvement of students in a structured research program. Instead of a single faculty member working with a single student, project teams consisting of two or more faculty will be formed to develop cross discipline projects. A special effort to recruit dual biology/chemistry major students, who have tended not to be involved in research, will be made to increase their participation.