Integration of FT-NMR into the Undergraduate Chemistry Curriculum

将 FT-NMR 纳入本科化学课程

• 批准号: 9551643
• 负责人: Michael Imhoff
• 金额: $ 9.47万
• 依托单位: Austin College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-11-01 至 1997-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9551643&HistoricalAwards=false
• 关键词: Integration; FT; NMR; into; Undergraduate

The chemistry department is purchasing a modem high-field nuclear magnetic resonance (NMR) spectrometer to enable its students to learn modern techniques in structure determination. The instrument is being used at all levels of the curriculum and leads students to a more sophisticated understanding of the power of NMR techniques to unlock chemical secrets. Beginning with organic chemistry, students learn to interpret coupling patterns and chemical shifts in 1H and 13C spectra to identify molecular structure. At the next level, in Instrumental Methods, the introduction to Fourier transform and quantitative measurements provides a theoretical basis for better understanding FT-NMR. In upper-level courseq students gain experience in a rich array of techniques available to a multinuclear high-field NMR. For instance, biochemistry students study the stereochemistry of an enzymatic reaction and observe structural variations in protein structures, and in physical chemistry they determine the kinetics of an exchange reaction and study the thermodynamics of an equilibrium reaction. The presence of the FT-NMR spectrometer enhances the undergraduate research program and is used for routine analysis of products prepared in inorganic synthesis.

化学系正在购置一台现代高场核磁共振光谱仪，使学生能够学习现代结构测定技术。该仪器被用于课程的各个层次，并引导学生更深入地了解核磁共振技术解开化学秘密的力量。从有机化学开始，学生学习解释1H和13C光谱中的耦合模式和化学位移，以识别分子结构。在下一层次，在仪器方法中，介绍傅里叶变换和定量测量为更好地理解FT-NMR提供了理论基础。在高级课程中，学生将获得丰富的多核高场核磁共振技术的经验。例如，生物化学学生研究酶促反应的立体化学，观察蛋白质结构的结构变化；物理化学学生确定交换反应的动力学，研究平衡反应的热力学。FT-NMR谱仪的出现增强了本科生的研究计划，并用于无机合成产物的常规分析。