Organic Osmolyte Channels and Cell Volume Regulation in Fish Erythrocytes

鱼红细胞的有机渗透通道和细胞体积调节

• 批准号: 9505567
• 负责人: Leon Goldstein
• 金额: $ 43.24万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9505567&HistoricalAwards=false
• 关键词: Organic; Osmolyte; Channels; Cell; Volume

9505567 Goldstein Body cells must maintain their volume constant in order to function properly. Both humans and animal cells face constant threats to their volumes under both physiological and pathological conditions. In this proposal, Dr. Goldstein will be examining the cellular and molecular mechanisms that permit cells to maintain constant volume in the face of osmotic disturbances in the environment surrounding cells. The experimental model will be the red blood cell of the skate. He has used this model successfully in the past to begin elucidating the physiological processes in the cell membrane that are involved in adjusting cell volume back to normal after extracellular disturbances. He will continue with these studies as well as others that deal with the ways in which cell volume changes are signaled to volume-adjustilg mechanisms operating in the cell membrane. The studies will lead to a better understanding of the physiological basis of the fundamethal phenomemon of cell volume regulation. ***

小行星9505567 身体细胞必须保持其体积恒定，以便正常工作。 人类和动物细胞在生理和病理条件下都面临着不断的体积威胁。 在这项提案中，Goldstein博士将研究细胞和分子机制，这些机制允许细胞在面对细胞周围环境的渗透干扰时保持恒定的体积。 实验模型将是红细胞的滑冰。 他在过去成功地使用这个模型来开始阐明细胞膜中的生理过程，这些过程涉及在细胞外干扰后将细胞体积调节回正常。 他将继续这些研究，以及其他处理细胞体积变化的方式，以细胞膜中的体积调节机制。 这些研究将使人们更好地了解细胞体积调节的基本现象的生理基础。 ***