Proteasome Workshop (July 1-3, 1995) to be held at Colorado State University, Fort Collins, CO.

MCB-9522216 Mykles 蛋白酶体是一种多聚体、多催化性蛋白酶复合物，在真核生物细胞内蛋白质水解中起核心作用。 作为26 S蛋白酶复合物的催化核心，它介导泛素化蛋白的ATP依赖性降解。 很少有研究人员聚会和讨论他们在蛋白酶体方面的工作的论坛。 因此，由Donald L. Mykles和其他人将于1995年7月1日至3日在科罗拉多州立大学（柯林斯堡CO）校园举行。 这是第一次在美国召开关于蛋白酶体的研讨会。 初步计划包括一个海报会议和五个口头会议，围绕结构和催化特性的主题组织;变构调节剂和合成抑制剂; 20 S和26 S复合物的表达，加工和组装;和生理功能。 会议将集中于最近的发展，阿萨内源性调节剂和20 S ATP酶复合物的分离，细胞渗透性抑制剂的合成，酵母中编码蛋白酶体亚基的全套cDNA的克隆，以及替代其他亚基并改变复合物催化蛋白质的“非必需”亚基的鉴定。 该提案要求为15名主要发言人和8名妇女和/或少数民族的旅费提供部分支助。 主要发言人代表了在该领域做出重大贡献的大多数实验室，因此构成了研讨会的关键promamatic核心。 我们认识到促进和鼓励代表性不足的行业参与的重要性，因此在提案中包括对八名妇女和/或少数民族的旅行和注册费用的支持。 蛋白质组研讨会是一个及时的会议，研究细胞质的非膜结合细胞器。 蛋白酶体由参与其他细胞质蛋白质的细胞降解的蛋白质聚集体组成。 这些聚集体是具有尚未完全确定的催化性质的蛋白酶的差异沉降复合物。 会议将讨论复合物的分离和功能以及它们组成的单个蛋白质。 这是美国第一个专门针对这种新细胞器的研讨会。 将有五个口头会议，其中包括来自世界各地的发言者，以及海报会议。 资金的主要用途将是支付发言者的旅费，并为妇女和少数群体提供旅费和登记津贴。 ***

MCB-9522216 Mykles The proteasome is a multimeric, multicatalytic proteinase complex that plays a central role in intracellular proteolysis in eukaryotes. As the catalytic core of the 26S protease complex, it mediates the ATP-dependent degradation of ubiquitinylated proteins. There have been few forums for researchers to meet and discuss their work on the proteasome. Consequently, a Proteasome Workshop, organized by Donald L. Mykles and others will be held July 1-3 1995 on the campus of Colorado State University (Fort Collins CO). This is the first time that a workshop on the proteasome has been convened in the US. The preliminary program consists of one poster session and five oral session organized around the themes of structure and catalytic properties; allosteric regulators and synthetic inhibitors; expression, processing, and assembly of the 20S and 26S complexes; and physiological functions. The sessions will focus on recent developments, such asa the isolation of endgenous regulators and the 20S ATPase complex, the synthesis of cell-permeable inhibitors, the cloning of the complete set of cDNAs encoding proteasome subunits in yeast, and the indentification of "nonessential" subunits that replace other subunits and change the catalytic proteties of the complex. The proposal requests partial support for the travel costs of the 15 main speakers and eight women and/or minorites. The main speakers represent most of the laboratories making significant contributions in the field, and therefore constitute the critical promamatic core of the workshop. We recognize the importance of promoting and encouraging the particaption of under-represented induviduals, and therefore include in the proposal support for the travel and registration costs of eight women and/or minorities. %%% The Proteaome Workshop is a timely meeting which examines a non-membrane-bound organelle of the cytoplasm. The proteasome is comprised of aggregates of proteins involved in c ellular degradation of other cytoplasmic proteins. These aggregates are differentially sedimenting complexes of proteases with as yet incompletely defined catalytic properties. The meeting will address the isolation and function of the complexes and the individual proteins of which they are comprised. It is the first workshop in the US specifically addressing this new organelle. There will be five oral sessions which will include speakers from around the world, as well as poster session. The primary uses of the funding will be in defraying the travel costs of the speakers and in providing a travel and registration stipend for women and minorities. ***