Proteasome Workshop (July 1-3, 1995) to be held at Colorado State University, Fort Collins, CO.

蛋白酶体是一种多聚体、多催化的蛋白酶复合物，在真核生物的细胞内蛋白水解中起核心作用。作为26S蛋白酶复合物的催化核心，它介导atp依赖性的泛素化蛋白降解。很少有论坛供研究人员开会讨论他们在蛋白酶体方面的工作。因此，由Donald L. Mykles和其他人组织的蛋白酶体研讨会将于1995年7月1日至3日在科罗拉多州立大学（Fort Collins CO）校园举行。这是第一次在美国召开关于蛋白酶体的研讨会。初步计划包括围绕结构和催化性能主题组织的一次海报会议和五次口头会议；变构调节剂和合成抑制剂；20S和26S复合物的表达、加工和组装；生理功能。会议将集中讨论最近的进展，如内源性调节因子和20S atp酶复合物的分离，细胞渗透性抑制剂的合成，酵母蛋白酶体亚基编码的全套cdna的克隆，以及取代其他亚基和改变复合物催化蛋白的“非必需”亚基的鉴定。该提案要求部分支助15名主要发言者和8名妇女和（或）少数民族的旅费。主要发言人代表了在该领域作出重大贡献的大多数实验室，因此构成了讲习班的关键宣传核心。我们认识到促进和鼓励代表性不足的个人参与的重要性，因此在提案中列入了对8名妇女和（或）少数民族的旅费和登记费用的支助。蛋白质组研讨会是一个及时的会议，研究细胞质的非膜结合细胞器。蛋白酶体由参与其他细胞质蛋白的细胞降解的蛋白质聚集体组成。这些聚合体是蛋白酶的不同沉淀复合物，具有尚未完全确定的催化特性。会议将讨论这些复合物及其组成的单个蛋白质的分离和功能。这是美国第一个专门针对这种新细胞器的研讨会。将有五场口头会议，包括来自世界各地的演讲者，以及海报会议。这笔资金的主要用途将是支付发言者的旅费和为妇女和少数民族提供旅费和登记津贴。＊＊＊

MCB-9522216 Mykles The proteasome is a multimeric, multicatalytic proteinase complex that plays a central role in intracellular proteolysis in eukaryotes. As the catalytic core of the 26S protease complex, it mediates the ATP-dependent degradation of ubiquitinylated proteins. There have been few forums for researchers to meet and discuss their work on the proteasome. Consequently, a Proteasome Workshop, organized by Donald L. Mykles and others will be held July 1-3 1995 on the campus of Colorado State University (Fort Collins CO). This is the first time that a workshop on the proteasome has been convened in the US. The preliminary program consists of one poster session and five oral session organized around the themes of structure and catalytic properties; allosteric regulators and synthetic inhibitors; expression, processing, and assembly of the 20S and 26S complexes; and physiological functions. The sessions will focus on recent developments, such asa the isolation of endgenous regulators and the 20S ATPase complex, the synthesis of cell-permeable inhibitors, the cloning of the complete set of cDNAs encoding proteasome subunits in yeast, and the indentification of "nonessential" subunits that replace other subunits and change the catalytic proteties of the complex. The proposal requests partial support for the travel costs of the 15 main speakers and eight women and/or minorites. The main speakers represent most of the laboratories making significant contributions in the field, and therefore constitute the critical promamatic core of the workshop. We recognize the importance of promoting and encouraging the particaption of under-represented induviduals, and therefore include in the proposal support for the travel and registration costs of eight women and/or minorities. %%% The Proteaome Workshop is a timely meeting which examines a non-membrane-bound organelle of the cytoplasm. The proteasome is comprised of aggregates of proteins involved in c ellular degradation of other cytoplasmic proteins. These aggregates are differentially sedimenting complexes of proteases with as yet incompletely defined catalytic properties. The meeting will address the isolation and function of the complexes and the individual proteins of which they are comprised. It is the first workshop in the US specifically addressing this new organelle. There will be five oral sessions which will include speakers from around the world, as well as poster session. The primary uses of the funding will be in defraying the travel costs of the speakers and in providing a travel and registration stipend for women and minorities. ***