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CRI: In Vivo Neural Gene Imaging Using a Novel Radiation Detector

CRI：使用新型辐射探测器进行体内神经基因成像

基本信息

批准号：
9602865
负责人：
Margaret Saha
金额：
$ 10万
依托单位：
College of William and Mary
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-01 至 1999-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9602865&HistoricalAwards=false
关键词：
CRI Vivo Neural Gene Imaging

项目摘要

IBN: 9602865 PI: Saha It is of great interest to neuroscientists studying brain development and function to be able to follow gene expression which is directed by the genetic code stored in each cell of an organism. Presently if one wants to understand what part of the genetic code is being used in a developing embryo of a laboratory mouse or what genes are activated in response to varous pharmacological treatments, one must sacrifice the organism and then use molecular biology techniques to study the genes being activated. This method is essentially taking only a 'snapshot' of the genetic processes occurring. One then needs to begin anew with another organism and hope to take another 'snapshot' at the right time. This proposed project will use new radiation imaging methods that have been developed for particle physics research together with techniques used in medical imaging to allow the neuroscientist to image the gene activation patterns in an organism in vivo, that is, without having to sacrifice the embryo. This will enable us to produce a continuous account of the genetic processes occurring within the nervous system. Our ultimate goal is to produce a detector system capable of imaging genes during development and in response to various experimental pharmacological treatments -- a system which will eventually be applied to better understanding and treating human neurological disease.

IBN: 9602865 PI: Saha 对于研究大脑发育和功能的神经科学家来说，能够追踪由存储在生物体每个细胞中的遗传密码指导的基因表达是非常感兴趣的。目前，如果人们想了解实验室小鼠发育中的胚胎中使用了遗传密码的哪一部分，或者哪些基因响应各种药物治疗而被激活，则必须牺牲生物体，然后使用分子生物学技术来研究被激活的基因。这种方法本质上只是拍摄正在发生的遗传过程的“快照”。然后，人们需要重新开始研究另一种有机体，并希望在正确的时间拍摄另一张“快照”。该项目将使用为粒子物理研究开发的新辐射成像方法以及医学成像技术，使神经科学家能够对生物体内的基因激活模式进行成像，而无需牺牲胚胎。这将使我们能够对神经系统内发生的遗传过程进行连续的描述。我们的最终目标是生产一种能够在发育过程中对基因进行成像并响应各种实验药理学治疗的检测器系统——该系统最终将用于更好地理解和治疗人类神经系统疾病。