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Is Nitric Oxide or a Prostaglandin the Endothelium-Derived Relaxing Factor in Fishes?

一氧化氮或前列腺素是鱼类内皮衍生的松弛因子吗？

基本信息

批准号：
9604824
负责人：
David Evans
金额：
$ 20.3万
依托单位：
University of Florida
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2001-03-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9604824&HistoricalAwards=false
关键词：
Nitric Oxide Prostaglandin Endothelium Derived

项目摘要

Blood vessels in vertebrates have a thin lining of cells termed the endothelium, which was generally thought to provide little more than some protection against the adhesion of blood cells (RBCs, platelets, etc.) to the vascular smooth muscle which underlies the endothelium on the vessel wall. However, in recent years, it has become apparent that endothelial cells produce a variety of chemical messengers that no only protect against blood clotting but also control the diameter of the vessel itself by stimulating contraction or relaxation of the vascular smooth muscle. The most famous of these is the so-called "endothelium-derived relaxing factor", which is not thought to be nitric oxide. This gas is now considered to be the dominant EDRF in mammals, despite the fact that the endothelial cells produce other dilatory substances, such as the prostaglandins PGI2 and PGE. Dr. Evans' preliminary evidence has shown that this may not be the case in early vertebrates such as the dogfish shark. In this species, the endothelial nitric oxide system appears to be absent, and PGE, not PGI2, appears to be the only EDRF. The PI is interested in delineating the evolution of the EDRF control system, determining which it appeared and what role it plays in cardiovascular control in various groups of fishes. This NSF award will allow him to make these determinations.

脊椎动物的血管有一层薄薄的细胞衬里，称为内皮，一般认为它除了提供一些保护，防止血细胞（红细胞、血小板等）粘附到血管壁上内皮下面的血管平滑肌上。然而，近年来，内皮细胞产生多种化学信使，不仅可以防止血液凝固，还可以通过刺激血管平滑肌的收缩或松弛来控制血管本身的直径。其中最著名的是所谓的“内皮衍生的放松因子”，它被认为不是一氧化氮。这种气体现在被认为是哺乳动物中主要的EDRF，尽管内皮细胞会产生其他扩张性物质，如前列腺素PGI2和PGE。埃文斯博士的初步证据表明，在角鲨等早期脊椎动物中，情况可能并非如此。在这个物种中，内皮一氧化氮系统似乎缺失，PGE而不是PGI2似乎是唯一的EDRF。PI感兴趣的是描述EDRF控制系统的演变，确定它是如何出现的，以及它在各种鱼类的心血管控制中起什么作用。这个国家科学基金会的奖励将允许他做出这些决定。