Integrative genomic and genetic analysis of nonhost resistance across Triticeae species (TritNONHOST)

小麦科物种非寄主抗性的综合基因组和遗传分析 (TritNONHOST)

• 批准号: 105799157
• 负责人: Professor Dr. Ulrich Schaffrath
• 金额: --
• 依托单位: Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/105799157?language=en
• 关键词: Integrative; genomic; genetic; analysis; nonhost

The scientific aim of this project is to identify and explore the genetic framework for nonhost resistance in wheat and barley to three pathogens of enormous economic and ecological impact causing rust (Puccinia spp.), powdery mildew (Blumeria spp.) and blast (Magnaporthe spp.) disease in cereals. A global, differential gene-expression analysis, comparing compatible host and nonhost interactions will allow the identification of common, plant species-specific and pathogen speciesspecific pathways involved in nonhost resistance in wheat and barley. Functional genomics approaches will be used to test the function of potential nonhost resistance genes in the corresponding cereal species for resistance to non-adapted as well as adapted pathogens. The functional data will be combined with quantitative genetic data from novel populations segregating for nonhost resistance, in order to provide convergent evidence for a role of candidate genes in nonhost resistance of Triticeae (Figure 1). The outputs from this project will provide us with a new level of understanding of the fundamental inner workings of the biology of nonhost resistance in cereals that will provide the European plant breeding industry with the knowledge and tools required to achieve sustainable resistance to major pathogens. The ultimate aim is to transfer the genetic components of nonhost resistance from one cereal to the other to achieve “nonhost-like” resistance to the adapted pathogen.

本项目的科学目的是鉴定和探索小麦和大麦对引起锈病(Puccinia spp.)、白粉病(Blumeria spp.)等三种具有巨大经济和生态影响的病原菌的非寄主抗性的遗传框架。和BLAST(Magnaporthe spp.)谷物中的疾病。一种全球性的差异基因表达分析，比较兼容的寄主和非寄主的相互作用，将有助于识别小麦和大麦中涉及非寄主抗性的常见的、植物物种特有的和病原物种特有的途径。功能基因组学方法将被用来测试相应谷物物种中潜在的非寄主抗性基因对非适应性和适应性病原菌的抗性。功能数据将与分离非寄主抗性的新群体的定量遗传数据相结合，以提供候选基因在小麦非寄主抗性中所起作用的聚合证据(图1)。该项目的成果将使我们对谷物非寄主抗性生物学的基本内部机制有一个新的了解，这将为欧洲植物育种行业提供实现对主要病原体的可持续抗性所需的知识和工具。最终目的是将非寄主抗性的遗传成分从一种谷物转移到另一种谷物，以实现对适应病原菌的“非寄主”抗性。