Purchase of Time-of-Flight Mass Spectrometer

购买飞行时间质谱仪

• 批准号: 9707658
• 负责人: David Hercules
• 金额: $ 23.2万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-15 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9707658&HistoricalAwards=false
• 关键词: Purchase; Time; Flight; Mass; Spectrometer

The acquisition of a matrix assisted laser desorption ionization time-of-flight mass spectrometer is supported by the Analytical and Surface Chemistry Program and the Office of Multidisciplinary Activities. Professor Hercules and his students at Vanderbilt University will use this instrument to study problems such as the characterization of diverse polymer systems, the rapid qualitative and quantitative analysis of thin-layer chromatography plates, the quantitative analysis of FKBP binding proteins to better understand its role in calcium homeostasis, and the detection of aflatoxins. This instrument is central to this research program and it will replace a failing fifteen year old instrument. A replacement mass spectrometer is being purchased with the capability of doing highly sensitive and selective analysis of complex organic and biological materials. The materials being studied cover a wide range of polymers and include important biological compounds such as the binding protein FKBP and the highly toxic aflatoxin B1. A very broad range of applications and methods of analysis will be developed using this instrument. Important components of this mass spectrometer include matrix assisted laser desorption ionization sample introduction and time- of-flight mass analysis.

矩阵辅助激光解吸电离飞行时间质谱仪的收购是由分析和表面化学方案和多学科活动办公室的支持。 范德比尔特大学的Hercules教授和他的学生们将利用这一仪器研究各种聚合物系统的表征、薄层色谱板的快速定性和定量分析、FKBP结合蛋白的定量分析以更好地了解其在钙稳态中的作用以及黄曲霉毒素的检测等问题。 该仪器是这项研究计划的核心，它将取代一个失败的15岁的仪器。 正在购买一台替代质谱仪，它有能力对复杂的有机和生物材料进行高灵敏度和选择性分析。 正在研究的材料涵盖广泛的聚合物，包括重要的生物化合物，如结合蛋白FKBP和高毒性黄曲霉毒素B1。 将使用该仪器开发非常广泛的应用和分析方法。 该质谱仪的重要组成部分包括基质辅助激光解吸电离进样和飞行时间质谱分析。