Acquisition of a 500 MHz NMR Spectrometer

核磁共振（NMR）光谱是最 化学家可以用来阐明 分子的结构 它用于识别未知 物质，表征内部原子的特定排列 分子，并研究相互作用的动力学之间 溶液中的分子。 获得最先进的NMR 光谱学对化学家来说是必不可少的， 前沿研究 化学共享仪器计划（Chemistry Shared Instruments Program） 将帮助牛津大学化学系 匹兹堡获得高场核磁共振光谱仪。 领域 化学研究，这将加强收购 包括以下步骤： 1)维生素B-12作用机制的研究 合成模型 2)硫试剂合成新方法的开发 3)亚烷基-烷基立体化学的测定 插入反应 4)天然产物的合成及新产品的开发 合成方法 5)复杂天然产物系统的构建 6)自由基时钟作为酶作用机制的探针 7)分子识别研究

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists who are carrying out frontier research. This award from the Chemistry Shared Instrumentation Program will help the Chemistry Department at the Univeristy of Pittsburgh to acquire a high-field NMR spectrometer. The areas of chemical research that will be enhanced by the acquisition include: 1) Study of the mechanism of action of vitamin B-12 through synthetic models 2) Development of new synthetic methods using sulfur reagents 3) The determination of the stereochemistry of alkylidene-alkyl insertion reactions 4) Natural product synthesis and the development of new synthetic methods 5) Construction of complex natural product systems 6) Free radical clocks as probes of enzyme mechanism 7) Studies in molecular recognition