Acquisition of a 500 MHz NMR Spectrometer

核磁共振（NMR）光谱是化学家用来研究分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱学对于正在进行前沿研究的化学家来说是必不可少的。这项来自化学共享仪器项目的资助将帮助匹兹堡大学化学系获得一台高场核磁共振光谱仪。此次收购将加强的化学研究领域包括：1)通过合成模型研究维生素B-12的作用机理2)利用硫试剂开发新的合成方法3)烷基烯-烷基插入反应立体化学的测定4)天然产物的合成及新合成方法的开发5)复杂天然产物体系的构建；6)自由基时钟作为酶机制的探针；7)分子识别研究

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists who are carrying out frontier research. This award from the Chemistry Shared Instrumentation Program will help the Chemistry Department at the Univeristy of Pittsburgh to acquire a high-field NMR spectrometer. The areas of chemical research that will be enhanced by the acquisition include: 1) Study of the mechanism of action of vitamin B-12 through synthetic models 2) Development of new synthetic methods using sulfur reagents 3) The determination of the stereochemistry of alkylidene-alkyl insertion reactions 4) Natural product synthesis and the development of new synthetic methods 5) Construction of complex natural product systems 6) Free radical clocks as probes of enzyme mechanism 7) Studies in molecular recognition