Physiological Basis of Metabolism and Activity: Plasticity and Prioritization of Cardiopulmonary Function in Elevated Metabolic States

代谢和活动的生理基础：高代谢状态下心肺功能的可塑性和优先顺序

• 批准号: 9727762
• 负责人: Albert Bennett
• 金额: $ 24.3万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9727762&HistoricalAwards=false
• 关键词: Physiological; Basis; Metabolism; Activity; Plasticity

9727762 Bennett This study examines how the pulmonary and cardiovascular systems respond to increased metabolic demands for increased oxygen delivery and carbon dioxide removal in very different tissues: the skeletal musculature and the intestine. Is the pattern of increased ventilation and circulation stereotyped, such that the same response (heart rate, stroke volume, breathing frequency, and tidal volume) is used for equal energetic demands in the two different tissues, or is it plastic, dependent on which tissue is active? If both tissues are active simultaneously, which receives priority allocation for oxygen delivery and carbon dioxide removal? Large reptiles will be used as model systems to investigate these patterns, because metabolic increments associated with digestion are extraordinarily large in these animals, approaching those associated with physical activity.

9727762班尼特这项研究探讨了肺和心血管系统如何响应增加的代谢需求，增加氧气输送和二氧化碳清除在非常不同的组织：骨骼肌肉组织和肠道。 增加通气和循环的模式是定型的，即相同的反应（心率、每搏输出量、呼吸频率和潮气量）用于两种不同组织的相等能量需求，还是可塑的，取决于哪种组织是活跃的？ 如果两个组织同时活跃，哪一个组织优先分配氧气输送和二氧化碳清除？ 大型爬行动物将被用作研究这些模式的模型系统，因为这些动物中与消化相关的代谢增量非常大，接近与体力活动相关的代谢增量。