Physiological Basis of Metabolism and Activity: The Cardiopulmonary Physiology of Digestion and Exercise

代谢和活动的生理学基础：消化和运动的心肺生理学

• 批准号: 0091308
• 负责人: Albert Bennett
• 金额: $ 36万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0091308&HistoricalAwards=false
• 关键词: Physiological; Basis; Metabolism; Activity; Cardiopulmonary

This research investigates cardiopulmonary (heart, lung, and circulatory) function during elevated metabolism. Previously, physiologists could only induce substantially elevated metabolism in ecotherms by exercising them. Hence, it was not possible to separate the elements of cardiopulmonary function associated with elevated metabolism per se from those elements specific to exercise. Recent experiments with reptiles have demonstrated that digestion may increase metabolism to levels equal to those during maximal activity. Elevated metabolism stimulated by exercise induces hyperventilation. Elevated metabolism stimulated by digestion induces hypoventilation. The investigators will undertake experiments to determine the physiological basis for hypoventilation during digestion. In other experiments, the investigators will measure gas exchange, blood gas and acid-base status, cardiac shunting and blood flow distribution simultaneously. They will compare animals subjected to various combinations of resting, exercising, feeding, and fasting to determine how the conflicting demands of digestion and exercise are resolved. This research will permit an understanding of the match between supply and demand in metabolic gas exchange and the identification of those elements that are stereotyped and state-independent from those that are flexible and state-dependent.

本研究调查了代谢升高期间的心肺（心脏、肺和循环）功能。以前，生理学家只能通过锻炼它们来诱导生态温泉的新陈代谢大幅提高。因此，不可能将与代谢升高相关的心肺功能要素本身与运动特有的要素分开。 最近对爬行动物的实验表明，消化可以将新陈代谢提高到与最大活动期间相等的水平。运动引起的新陈代谢增加会引起换气过度。 由消化刺激的代谢升高引起通气不足。 研究人员将进行实验，以确定消化过程中通气不足的生理基础。在其他实验中，研究者将同时测量气体交换、血气和酸碱状态、心脏分流和血流分布。 他们将比较动物的休息，运动，喂养和禁食的各种组合，以确定如何解决消化和运动的冲突需求。这项研究将允许代谢气体交换的供应和需求之间的匹配的理解和识别的那些元素是刻板的和状态独立的那些是灵活的和状态依赖的。