Tailored Solvents for Pollution Source Reduction in Phamaceutical & Fine Chemical Processing

用于减少制药污染源的定制溶剂

• 批准号: 9729404
• 负责人: Trevor Hatton
• 金额: $ 18万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-10-01 至 2000-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9729404&HistoricalAwards=false
• 关键词: Tailored; Solvents; Pollution; Source; Reduction

CTS-9729404 Hatton, T.A. MIT Abstract It is proposed to develop a new class of solvents that have solvation properties similar to those of solvents used conventionally in pharmaceutical and fine chemical processing but for which the potential for loss by environmentally-unfavorable air emissions or in aqueous discharge streams is minimized. A complete characterization of the new solvent is to be undertaken, and their role in minimizing the potential for pollution, and in reducing the number of solvent exchanges and unit operations required for specific processes will be evaluated. The economic and environmental impact assessment will include al aspects of the solvent usage, including its synthesis and any wastes that may be generated thereby. These new solvents will be obtained by suitable derivatization of the solvent tetrahydrofuran (THF) to be replaced to render it significantly less volatile or water soluble, and thus less inclined to enter the environment; the active solvent moiety will also be 'immobilized' by attachment to flexible polymers, which are then dissolved in a more benign continuous phase. These new solvents will be tested as reaction media for a broad range of model reaction systems, including a series of reactions that are important in the production of the HIV protease inhibitor Crixivan Detailed spectroscopic characterization as well as bulk thermodynamic properties will be used to rationalize the kinetics results in terms of steric and electronic effects introduced by the solvent modification. Process systems modeling will be carried out to quantify the economic and environmental impact of processes using these solvents, and compared with conventional systems. A new range of solvents will be developed and characterized in terms of their solvation, thermodynamic and transport properties, and tested for their efficacy as reaction media using a range of different model reactions. Guidelines will be established for product recovery and solvent regeneration, and process systems models will be developed for optimization of reaction/separation sequences in pharmaceutical and fine chemical syntheses. A life cycle analysis of these new solvents from synthesis through to use in processing, including solvent regeneration, will be made to delineate their useful application parameters.

CTS-9729404 Hatton，T.A. MIT 摘要 提出开发一类新的溶剂，其具有与常规用于制药和精细化学加工的溶剂类似的溶剂化性质，但其由环境不利的空气排放或含水排放流损失的可能性最小化。 将对新溶剂进行完整的表征，并将评价其在尽量减少污染可能性方面的作用，以及在减少特定工艺所需的溶剂交换和单元操作次数方面的作用。 经济和环境影响评估将包括溶剂使用的所有方面，包括其合成和由此可能产生的任何废物。 这些新溶剂将通过待替换的溶剂四氢呋喃（THF）的适当衍生化来获得，以使其挥发性或水溶性显著降低，因此不太倾向于进入环境;活性溶剂部分也将通过附着到柔性聚合物上而被“固定”，然后溶解在更良性的连续相中。 这些新的溶剂将被测试作为反应介质的广泛的模型反应系统，包括一系列的反应，是重要的生产的HIV蛋白酶抑制剂Crixivan详细的光谱表征以及大量的热力学性质将被用来合理化的动力学结果的空间和电子效应引入的溶剂修改。 将进行工艺系统建模，以量化使用这些溶剂的工艺的经济和环境影响，并与传统系统进行比较。 将开发一系列新的溶剂，并根据其溶剂化，热力学和传输特性进行表征，并使用一系列不同的模型反应测试其作为反应介质的功效。 将为产品回收和溶剂再生制定指导方针，并将为优化制药和精细化学品合成中的反应/分离顺序开发工艺系统模型。 将对这些新溶剂从合成到加工使用（包括溶剂再生）的生命周期进行分析，以描述其有用的应用参数。