Integration of NMR Spectroscopy across the Chemistry and Biochemistry Undergraduate Curriculum

核磁共振波谱学在化学和生物化学本科课程中的整合

• 批准号: 9952264
• 负责人: Murray Zanger
• 金额: $ 16.65万
• 依托单位: University of the Sciences in Philadelphia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9952264&HistoricalAwards=false
• 关键词: Integration; NMR; Spectroscopy; across; Chemistry

Chemistry (12) Nuclear magnetic resonance (NMR) is one of the most useful and versatile instrumental techniques currently available to researchers in all areas of chemistry. Despite its importance, NMR is typically covered incompletely, and oftentimes haphazardly, across the chemistry and biochemistry curricula. Typically, NMR is used for structural elucidation in organic chemistry and instrumental analysis courses. Most students graduate without knowing that NMR can also be used to study kinetics, thermodynamics, equilibria, and conformation, just to name a few applications. The main reasons for this weak emphasis on NMR instruction, even in institutions with large NMR research facilities, are the lack of a cohesive curricula plan and lack of broad faculty expertise. In this project, we address and overcome these deficiencies through the incorporation of the theory and practice of NMR spectroscopy across the chemistry and biochemistry undergraduate curricula, and training of the faculty. Students are introduced to NMR as early as their freshman year, with increasingly sophisticated experiences added in later courses. The program underway at Ursinus College is serving as an overall model for our program. The experiments and materials used in the implementation of the curricula changes derive from different sources. First, experiments developed by successful DUE-NSF funded programs at other institutions are being adapted to the student audience at USP in order to reflect their interest in biochemical and biomedical problems. Second, well-tested experiments aimed at undergraduates are being adapted from the literature, and, finally, faculty are developing novel experiments targeting specific problems. Furthermore, the availability of a modern high resolution NMR spectrometer allows students in all chemistry-related majors (e.g., chemistry, biochemistry, biology, pharmacology & toxicology) to perform undergraduate research at levels previously impossible at our institution. Since virtually all students at USP take one full year of chemistry, and 70% take three years, a very large number of young scientists will graduate with knowledge of multinuclear, multiple-pulse, and 2D NMR techniques, which will give them an important edge in their future careers.The project also is evaluating and disseminating the results from the undergraduate NMR program. In addition to conventional methods, such as presentation and publication of novel laboratory experiments and results from undergraduate research in peer-reviewed journals and at local and national meetings, we are using internet-based tools for program evaluation and dissemination. These tools also provide convenient routes for dissemination of materials to students and faculty, and they allow for rapid evaluation and program adaptation guided by student feedback.

化学（12）核磁共振（NMR）是目前化学所有领域研究人员可用的最有用和最通用的仪器技术之一。尽管它的重要性，核磁共振通常是涵盖不完全，往往是偶然的，在整个化学和生物化学课程。通常，NMR用于有机化学和仪器分析课程中的结构解析。大多数学生毕业时不知道NMR也可以用于研究动力学，热力学，平衡和构象，仅举几例应用。对NMR教学重视不够的主要原因，即使是在拥有大型NMR研究设施的机构中，也是缺乏有凝聚力的课程计划和缺乏广泛的教师专业知识。在这个项目中，我们解决和克服这些不足之处，通过合并的理论和实践的NMR光谱在化学和生物化学本科课程，并培训教师。学生们早在大一就开始学习NMR，在以后的课程中增加了越来越复杂的经验。在乌尔西诺学院正在进行的计划是作为我们计划的整体模型。在实施课程改革过程中使用的实验和材料来自不同的来源。首先，在其他机构成功的DUE-NSF资助的项目开发的实验正在适应学生观众在USP，以反映他们的兴趣在生物化学和生物医学问题。第二，针对本科生的经过良好测试的实验正在从文献中改编，最后，教师正在开发针对特定问题的新实验。此外，现代高分辨率NMR光谱仪的可用性允许所有化学相关专业的学生（例如，化学，生物化学，生物学，药理学毒理学）进行本科研究水平以前不可能在我们的机构。由于几乎所有的学生在南太平洋大学的化学需要一个完整的一年，70%的学生需要三年，非常多的年轻科学家将毕业的多核，多脉冲和二维核磁共振技术的知识，这将给他们在未来的职业生涯中的重要优势。该项目也是评估和传播的结果，从本科核磁共振计划。除了传统方法外，例如在同行评审期刊以及地方和国家会议上展示和发表新颖的实验室实验和本科生研究结果，我们还使用基于互联网的工具进行项目评估和传播。这些工具还为向学生和教师传播材料提供了方便的途径，并允许在学生反馈的指导下进行快速评估和程序调整。