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Late-Metal Metallacyclobutene Chemistry

后金属金属环丁烯化学

基本信息

批准号：
9975939
负责人：
Joseph O'Connor
金额：
$ 34.7万
依托单位：
University of California-San Diego
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-01 至 2003-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9975939&HistoricalAwards=false
关键词：
Late Metal Metallacyclobutene Chemistry

项目摘要

In this project, which is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program, Dr. Joseph O'Connor of the University of California - San Diego will pursue an investigation of the synthesis, structural elucidation, and mechanistic aspects of the formation and reactions of metallacyclobutene complexes. Even though these species play important roles in a number of metal-mediated transformations, there are relatively few well characterized examples. Thus, new synthetic routes will be devised for late-transition metallacyclobutene complexes. These compounds will be used for structural studies, well defined reactivity studies, the development of new reactions, and the modeling of key steps in reactions that are thought to involve metallacyclobutene intermediates. In addition to uncovering new synthetic approaches to and applications of these complexes, the proposed studies will address stereocontrol of their synthesis and reactions.This project involves investigations of the preparation and reactivity of a class of organometallic compound known as metallacyclobutenes. The examples of interest for these studies contain late transition elements. The major objective is the development of new synthetic methods that may be used in total synthesis of natural products and their homologs. As such, the new methods will be valuable to the preparation of pharmaceuticals.

在这个由无机、生物无机和有机金属化学项目支持的项目中，加州大学圣地亚哥分校的 Joseph O'Connor 博士将研究金属环丁烯络合物的合成、结构阐明以及形成和反应的机理。尽管这些物种在许多金属介导的转化中发挥着重要作用，但明确表征的例子相对较少。因此，将为后过渡金属环丁烯配合物设计新的合成路线。这些化合物将用于结构研究、明确的反应性研究、新反应的开发以及被认为涉及金属环丁烯中间体的反应中关键步骤的建模。除了揭示这些配合物的新合成方法和应用之外，拟议的研究还将解决其合成和反应的立体控制问题。该项目涉及一类称为金属环丁烯的有机金属化合物的制备和反应性的研究。这些研究感兴趣的例子包含晚期过渡元素。主要目标是开发可用于天然产物及其同系物全合成的新合成方法。因此，新方法对于药物的制备很有价值。