Metallacyclobutene and Vinylcarbene Reaction Chemistry

金属环丁烯和乙烯基碳烯反应化学

• 批准号: 0911765
• 负责人: Joseph O'Connor
• 金额: $ 43.8万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911765&HistoricalAwards=false
• 关键词: Metallacyclobutene; Vinylcarbene; Reaction; Chemistry

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the efforts of Professor Joseph M. O'Connor of the University of California San Diego to investigate late-metal metallacyclobutene complexes. Such complexes have been proposed as key intermediates in a large number of important metal-mediated transformations, including alkyne polymerizations, enyne methathesis reactions, and in the synthesis of cyclopropenes, furans, pyrones, and benzannulated compounds. The development of new synthetic routes to these targets maximizes the potential for subsequent reactivity. Isolable metallacyclobutene complexes allow for: a) structural studies, b) well-defined reactivity studies, c) the development of new reactions, d) appropriate modeling of key steps in reactions which are thought to involve metallacyclobutene intermediates, and e) applications of metallacyclobutene-derived products in many areas of the chemical sciences. Undergraduate and graduate students trained in the area of organometallic chemistry are well-positioned to make important contributions to both industrial and academic endeavors which require interdisciplinary research in areas such as materials, inorganic and organic chemistry.

无机，生物无机和有机化学计划支持约瑟夫M教授的努力。加州圣地亚哥大学的奥康纳研究了后金属环丁烯络合物。 此类配合物已被提出作为大量重要的金属介导的转化中的关键中间体，包括炔聚合、烯炔甲基化反应，以及环丙烯、呋喃、吡喃酮和苯并环化合物的合成。 这些目标的新合成路线的开发最大化了后续反应的潜力。 可分离的金属环丁烯络合物允许：a）结构研究，B）明确定义的反应性研究，c）开发新反应，d）被认为涉及金属环丁烯中间体的反应中关键步骤的适当建模，和e）金属环丁烯衍生产物在化学科学的许多领域中的应用。 在有机金属化学领域接受培训的本科生和研究生能够为工业和学术事业做出重要贡献，这些事业需要在材料，无机和有机化学等领域进行跨学科研究。