Metallacyclobutene and Vinylcarbene Reaction Chemistry

无机化学、生物无机化学和金属有机化学计划支持加州大学圣地亚哥分校的约瑟夫·M·奥康纳教授研究晚金属环丁烯化合物的努力。这类化合物已被认为是许多重要的金属催化转化反应的关键中间体，包括炔烃聚合、烯炔合成反应，以及环丙烯、呋喃、吡喃和苯环化合物的合成。开发通向这些目标的新的合成路线可以最大限度地提高后续反应的潜力。可分离的金属环丁烯络合物允许：a)结构研究，b)明确的反应性研究，c)新反应的开发，d)被认为涉及金属环丁烯中间体的反应中关键步骤的适当模拟，以及e)金属环丁烯衍生产物在化学科学的许多领域的应用。在有机金属化学领域接受培训的本科生和研究生能够为需要在材料、无机化学和有机化学等领域进行跨学科研究的工业和学术努力做出重要贡献。

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the efforts of Professor Joseph M. O'Connor of the University of California San Diego to investigate late-metal metallacyclobutene complexes. Such complexes have been proposed as key intermediates in a large number of important metal-mediated transformations, including alkyne polymerizations, enyne methathesis reactions, and in the synthesis of cyclopropenes, furans, pyrones, and benzannulated compounds. The development of new synthetic routes to these targets maximizes the potential for subsequent reactivity. Isolable metallacyclobutene complexes allow for: a) structural studies, b) well-defined reactivity studies, c) the development of new reactions, d) appropriate modeling of key steps in reactions which are thought to involve metallacyclobutene intermediates, and e) applications of metallacyclobutene-derived products in many areas of the chemical sciences. Undergraduate and graduate students trained in the area of organometallic chemistry are well-positioned to make important contributions to both industrial and academic endeavors which require interdisciplinary research in areas such as materials, inorganic and organic chemistry.