Chemistry at the Alkyne - Carbene Intersection

炔烃-卡宾交叉点的化学

• 批准号: 1214024
• 负责人: Joseph O'Connor
• 金额: $ 49.7万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1214024&HistoricalAwards=false
• 关键词: Chemistry; Alkyne; Carbene; Intersection

With the support of an award from the Chemical Structure, Dynamics and Mechanism Program (CSDM) at the National Science Foundation, Professor Joseph M. O'Connor of the University of California, San Diego will lead a research program that will investigate the chemistry of metallacyclobutene and vinylcarbene complexes. Such complexes have been widely proposed as intermediates or transition state structures in metal-catalyzed reactions that impact the fields of organic synthesis, polymer chemistry, pharmaceuticals, material science and theory. The approach will involve a combination of synthetic, structural, computational and mechanistic work. Targeted molecules are chosen to maximize the potential for subsequent reactivity and to reveal mechanistic features of new and existing chemical transformations. The proposed chemistry will advance the fundamental knowledge base of organic, inorganic, and organometallic processes, and contribute to future advances in the environmentally friendly construction of molecules with useful properties. A key objective of the proposed studies it the interdisciplinary training of graduate students in the area of organometallic chemistry which will position them to make important scientific contributions to both industrial and academic endeavors.

在美国国家科学基金会化学结构、动力学和机理项目（CSDM）的资助下，约瑟夫·M·加州大学圣地亚哥分校的奥康纳将领导一项研究计划，研究金属环丁烯和乙烯基卡宾络合物的化学性质。 此类配合物已被广泛提议作为金属催化反应中的中间体或过渡态结构，其影响有机合成、高分子化学、药物、材料科学和理论领域。 该方法将涉及综合、结构、计算和机械工作的结合。 选择靶向分子以最大化后续反应的潜力，并揭示新的和现有的化学转化的机制特征。 拟议的化学将推进有机，无机和有机金属工艺的基础知识，并有助于未来的进步，在环境友好的建设具有有用的性能的分子。 拟议研究的一个关键目标是对有机金属化学领域的研究生进行跨学科培训，使他们能够为工业和学术事业做出重要的科学贡献。