Metal-Coordinated Biradicals as Synthetic Intermediates

作为合成中间体的金属配位双自由基

• 批准号: 0616576
• 负责人: Joseph O'Connor
• 金额: $ 44.4万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616576&HistoricalAwards=false
• 关键词: Metal; Coordinated; Biradicals; Synthetic; Intermediates

This project is focused on the development of fundamentally new synthetic methodology based on the intermediacy of novel metal-coordinated biradicals. Mechanistic and computational studies are to be employed in order to understand recently discovered metal-catalyzed Bergman cycloaromatization reactions. A single metal center will be employed to induce the formation of biradicals, transmit stereochemical information to remote bond-forming locations, and activate adjacent aromatic rings for subsequent stereoselective functionalization. Studies will also include the development of metal-triggered hetero-Bergman cycloaromatization reactions for the formation of heterocyclic compounds of synthetic importance. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Joseph M. O'Connor of the Department of Chemistry at University of California-San Diego. Professor O'Connor's research efforts revolve around the development of new synthetic methodology based on novel metal-coordinated biradicals. Such metal-coordinated biradicals offer promise for efficient approaches for the synthesis of complex organic molecules as well as the preparation of molecules that are virtually inaccessible in the absence of such radicals.

该项目的重点是开发基于新型金属配位双自由基的中间体的全新合成方法。 机理和计算的研究，以了解最近发现的金属催化Bergman环芳构化反应。 单个金属中心将用于诱导双自由基的形成，将立体化学信息传递到远程键形成位置，并活化相邻的芳环用于随后的立体选择性官能化。 研究还将包括开发金属触发的杂伯格曼环芳构化反应，以形成具有合成重要性的杂环化合物。有了这个奖项，有机和高分子化学计划是支持约瑟夫M教授的研究。加州大学圣地亚哥分校化学系的奥康纳说。 奥康纳教授的研究工作围绕着基于新型金属配位双自由基的新合成方法的发展。 这种金属配位的双自由基为合成复杂的有机分子以及制备在不存在这种自由基的情况下几乎不可接近的分子提供了有效的方法。