Synthetic, Structural and Mechanistic Metallacyclobutene Chemistry

金属环丁烯的合成、结构和机理化学

• 批准号: 9520213
• 负责人: Joseph O'Connor
• 金额: $ 30.6万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-01-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9520213&HistoricalAwards=false
• 关键词: Synthetic; Structural; Mechanistic; Metallacyclobutene; Chemistry

In this project which is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program, Dr. Joseph O'Connor of the University of California, San Diego will pursue an investigation of the synthesis, structural elucidation, and mechanistic aspects of formation and reaction of metallacyclobutene complexes. Dr. O'Connor has already discovered one method that should produce a range of metallacyclobutenes of late transition metals where there is a paucity of examples and even fewer studies of reactivity. Reactions to be studied include conversion of the metallacyclobutenes to cyclopentadienes and other five-membered rings, which are useful intermediates for organic synthesis, by reactions with alkynes and olefins. A novel photochromic effect that was observed in the substitution reaction of phosphorus donors in one cobaltacyclobutene complex will be examined by time-resolved spectroscopic methods. This project involves fundamental investigations of the synthesis and reactivity of a new class of organometallic compound known as metallacyclobutenes. The examples of interest for these studies contain late transition elements. The major objective is the development of new synthetic methods that may be used in total synthesis of natural products and their homologs. Some of these may ultimately find application as new pharmaceuticals.

在这个由无机，生物无机和 有机化学项目，约瑟夫奥康纳博士的大学 位于加州的圣地亚哥将对合成进行调查， 结构解析以及形成和反应的机理方面 金属环丁烯配合物。 奥康纳博士已经发现了一个 一种新的生产金属环丁烯的方法， 过渡金属的例子很少，甚至更少 反应性的研究。 待研究的反应包括金属环丁烯转化为环戊二烯和其它五元环， 它们是有机合成的有用中间体， 炔和烯烃。 一种新的光致变色效应， 一种环丁烯钴中磷给体取代反应 将通过时间分辨光谱方法检查复合物。 该项目涉及合成的基础研究， 反应性的一类新的有机金属化合物称为 金属环丁烯。 这些研究的相关实例包括： 后过渡元素。 主要目标是开发新的 可用于天然产物全合成的合成方法 及其同系物。 其中一些可能最终会发现新的应用程序 大药厂