Integration of Fourier Transform-Nuclear Magnetic Resonance Spectroscopy and Gas Chromatography/Mass Spectrometry into the Undergraduate Curriculum

化学(12)这个项目致力于通过实施解决问题的、以项目为基础的有机化学实验室计划来振兴和改变化学课程。这个项目为学生提供了丰富的实践经验，特别是那些使用傅立叶变换核磁共振(FT-核磁共振)光谱仪和气相色谱-质谱仪(GC-MS)的学生。学生积极学习有机化学的概念，使用FT-核磁共振和GC-MS来解决问题，改编自已发表的、成功的实验室实验，主要来自《化学教育杂志》。计划了几个学生项目，让学生获得和解释核磁共振和GC-MS，例如通过质子去耦合和无失真增强的极化转移(DEPT)13C核磁共振光谱来阐明烷烃的结构，以及通过GC-MS鉴定葡萄酒的芳香成分。除了有机化学，这些仪器还被纳入其他实验室课程，如高级有机化学，在这门课程中，学生表征有机锡化合物，通过核磁共振和GCMS的同位素分布模式来探索异核自旋耦合，以及分析化学，在分析化学中，学生从银杏提取物中分析复杂的混合物。对学生的预期结果包括发展FT-核磁共振和GC-MS操作的市场技能，提高解释光谱数据的能力，提高对化学在社会中的效用的认识，以及对化学的热情高涨。将FT-核磁共振和GC-MS结合到化学课程中，还通过培训来鼓励教师的发展，以便设计新的学生实验和与本科生进行研究。学生熟练操作核磁共振和GC-MS计算机工作站也有助于将技术融入教育。

Chemistry (12) This project works to revitalize and transform the chemistry curriculum through the implementation of a problem-solving, project-based laboratory program for Organic Chemistry. This program provides students with enriching "hands on" experiences, especially those using a Fourier Transform Nuclear Magnetic Resonance (FT-NMR) spectrometer and a Gas Chromatograph-Mass Spectrometer (GC-MS). Students actively learn the concepts of organic chemistry using FT-NMR and GC-MS to solve problems adapted from published, successful laboratory experiments, largely from the Journal of Chemical Education. Several student projects are planned that engage students in the acquisition and interpretation of NMR and GC-MS, such as the structural elucidation of alkanes by proton-decoupled and distortionless enhancement by polarization transfer (DEPT) 13C NMR spectroscopy and the identification of the fragrant components of wine by GC-MS. In addition to Organic Chemistry, these instruments are being incorporated into other laboratory courses such as Advanced Organic Chemistry, wherein students characterize an organotin compound to explore heteronuclear spin coupling by NMR and isotope distribution patterns by GCMS, and Analytical Chemistry, wherein students analyze complex mixtures from Ginko extracts. Expected outcomes for students include the development of marketable skills in the operation of FT-NMR and GC-MS, improved ability in the interpretation of spectral data, increased awareness of the utility of chemistry in society, and heightened enthusiasm for chemistry. Incorporation of FT-NMR and GC-MS into the chemistry curriculum also encourages faculty development via training in order to design new student experiments and to conduct research with undergraduates. Proficient operation of the NMR and GC-MS computer workstations by students also serves to integrate technology into education.