Integration of Fourier Transform-Nuclear Magnetic Resonance Spectroscopy and Gas Chromatography/Mass Spectrometry into the Undergraduate Curriculum

将傅里叶变换-核磁共振波谱和气相色谱/质谱分析纳入本科课程

• 批准号: 9980670
• 负责人: Dennis Gravert
• 金额: $ 6.48万
• 依托单位: Saint Mary's University of Minnesota
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9980670&HistoricalAwards=false
• 关键词: Integration; Fourier; Transform; Nuclear; Magnetic

Chemistry (12) This project works to revitalize and transform the chemistry curriculum through the implementation of a problem-solving, project-based laboratory program for Organic Chemistry. This program provides students with enriching "hands on" experiences, especially those using a Fourier Transform Nuclear Magnetic Resonance (FT-NMR) spectrometer and a Gas Chromatograph-Mass Spectrometer (GC-MS). Students actively learn the concepts of organic chemistry using FT-NMR and GC-MS to solve problems adapted from published, successful laboratory experiments, largely from the Journal of Chemical Education. Several student projects are planned that engage students in the acquisition and interpretation of NMR and GC-MS, such as the structural elucidation of alkanes by proton-decoupled and distortionless enhancement by polarization transfer (DEPT) 13C NMR spectroscopy and the identification of the fragrant components of wine by GC-MS. In addition to Organic Chemistry, these instruments are being incorporated into other laboratory courses such as Advanced Organic Chemistry, wherein students characterize an organotin compound to explore heteronuclear spin coupling by NMR and isotope distribution patterns by GCMS, and Analytical Chemistry, wherein students analyze complex mixtures from Ginko extracts. Expected outcomes for students include the development of marketable skills in the operation of FT-NMR and GC-MS, improved ability in the interpretation of spectral data, increased awareness of the utility of chemistry in society, and heightened enthusiasm for chemistry. Incorporation of FT-NMR and GC-MS into the chemistry curriculum also encourages faculty development via training in order to design new student experiments and to conduct research with undergraduates. Proficient operation of the NMR and GC-MS computer workstations by students also serves to integrate technology into education.

本项目旨在通过实施一个解决问题的、以项目为基础的有机化学实验计划来振兴和改造化学课程。该计划为学生提供丰富的“动手”经验，特别是使用傅里叶变换核磁共振（FT-NMR）光谱仪和气相色谱-质谱仪（GC-MS）的经验。学生积极学习有机化学的概念，使用FT-NMR和GC-MS来解决已发表的、成功的实验室实验中的问题，这些实验主要来自化学教育杂志。计划了几个学生项目，让学生参与核磁共振和气相色谱-质谱的获取和解释，例如用质子解耦和偏振转移（DEPT） 13C核磁共振波谱的无扭曲增强来阐明烷烃的结构，用气相色谱-质谱鉴定葡萄酒的芳香成分。除了有机化学之外，这些仪器也被纳入其他实验课程，如高级有机化学，其中学生表征有机锡化合物，通过核磁共振和同位素分布模式探索异核自旋耦合，以及分析化学，其中学生分析银杏提取物的复杂混合物。期望的结果包括培养学生在FT-NMR和GC-MS操作方面的市场技能，提高光谱数据解释的能力，提高对化学在社会中的效用的认识，以及提高对化学的热情。将FT-NMR和GC-MS纳入化学课程也鼓励教师通过培训来发展，以便设计新的学生实验并与本科生一起进行研究。学生熟练操作核磁共振和气相色谱-质谱计算机工作站也有助于将技术融入教育。