Fabrication of Integrated Polymeric Microfluidic Systems

集成聚合物微流体系统的制造

• 批准号: 0004030
• 负责人: George Whitesides
• 金额: $ 118.36万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0004030&HistoricalAwards=false
• 关键词: Fabrication; Integrated; Polymeric; Microfluidic; Systems

Whitesides0004030The principal objective in this work is to develop functional microfluidic devices based on PDMS and related materials. The strategic intent is to develop the simplest possible platform (meaning complete system, with components that accomplish sample introduction, preparation, separation, detection, disposal). We will fabricate integrated microanalytical systems using primarily poly(dimethylsiloxane) (PDMS) (and other organic polymers).The work will require development of a number of subsystems and components. The objectives of this work will be both to accomplish the task of developing a flexible platform technology, and to demonstrate new concepts. More specifically, the work will include: i) establishing the capability of PDMS to make certain types of functions uniquely possible by virtue of its flexibility and low surface free energies, and ii) expanding the range of components available to designers of microfluidic systems. The focus will be on proteomics rather than geonimcs.The PI will explore these ideas or components: * Laminar flow and counterflow as the basis for separations, for patterning and dosing cells and proteins, and for in-channel fabrication.* New types of functional components: on-chip equivalents of filters, dialysis chambers, magnetic sorters, ion exchange adsorbers and membranes, and centrifuges (with no moving parts).* Components with moving parts: new types of components with moving parts, taking advantage of the ability of PDMS to flex to eliminate hinges and other complex features that are required when using silicon.* Systems for separation and analysis of proteins that are amenable to chip-scale realization.

Whitesides 0004030本工作的主要目标是开发基于PDMS和相关材料的功能性微流体器件。 战略意图是开发尽可能简单的平台（即完整的系统，包括完成样品导入、制备、分离、检测和处置的组件）。我们将主要使用聚二甲基硅氧烷（PDMS）（和其他有机聚合物）制造集成微量分析系统。这项工作将需要开发许多子系统和组件。 这项工作的目标是完成开发灵活平台技术的任务，并展示新概念。 更具体地说，这项工作将包括：i）建立PDMS的能力，使某些类型的功能独特的凭借其灵活性和低表面自由能，和ii）扩大组件的范围可供设计师的微流体系统。 主要研究者将探索这些想法或组件：* 层流和逆流作为分离的基础，用于细胞和蛋白质的图案化和给药，以及通道内制造。*新型功能组件：过滤器、透析室、磁分选器、离子交换吸附器和膜以及离心机（无移动部件）的片上等效组件。*带活动部件的组件：具有活动部件的新型组件，利用PDMS的柔性，消除了使用硅时所需的铰链和其他复杂功能。*适用于芯片级实现的蛋白质分离和分析系统。