Molecular and Mesoscopic Self-Assembly

分子和介观自组装

• 批准号: 9901358
• 负责人: George Whitesides
• 金额: $ 40.9万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9901358&HistoricalAwards=false
• 关键词: Molecular; Mesoscopic; Self; Assembly

This research project explores the non-covalent chemistry of molecules and materials. The design and characterization of aggregates of molecules or small objects held together by non-covalent interactions will be undertaken and understood through the principles of physical organic chemistry. In particular, meso-scale particles at interfaces and in suspension, oligovalent species in solution, and molecular crystals will be studied in order to develop unifying principles extending those being uncovered in the areas of molecular self-assembly and supramolecular chemistry.With this Award, the Organic and Macromolecular Chemistry Program of the Division of Chemistry and the Solid State Chemistry and Polymers Program of the Division of Materials Research jointly fund a research project to be carried out by Professor George M. Whitesides of Harvard University. This project explores the nature of binding interactions that occur between molecules and aggregates thereof, in order to better understand the reasons why definite shapes are sometimes adopted, and why some interactions are stronger than others. One example involves the extraordinarily tight binding of certain bacterial peptides by the antibiotic vancomycin. Another involves the prediction of solid state structures of organic crystals, an important class of materials with new applications emerging in areas from optoelectronics to drug bioavailability.

本研究项目探索分子和材料的非共价化学。 通过非共价相互作用结合在一起的分子或小物体的聚集体的设计和表征将通过物理有机化学的原理进行和理解。 特别是，将研究界面和悬浮液中的介观尺度颗粒、溶液中的寡价物种和分子晶体，以发展统一的原则，扩展分子自组装和超分子化学领域的研究成果。化学系的有机和高分子化学项目和材料研究系的固态化学和聚合物项目共同资助一项研究计划，由乔治M.我是哈佛大学的怀特塞德。 该项目探讨了分子及其聚集体之间发生的结合相互作用的性质，以便更好地理解为什么有时采用特定形状的原因，以及为什么某些相互作用比其他相互作用更强。 一个例子涉及抗生素万古霉素与某些细菌肽的异常紧密结合。 另一个涉及预测有机晶体的固态结构，这是一类重要的材料，在光电子学和药物生物利用度等领域都有新的应用。