Supramolecular Redox-active and Inactive Systems Derived From Hemilabile Ligands

无机化学、生物无机化学和金属有机化学项目的这一奖项支持西北大学化学系的查德·米尔金教授的研究，该研究利用具有氧化还原活性的半碱基配体(RHLS)来控制过渡金属中心的配位。合成了一系列化合物，包括Ru的聚三硫烯RHL络合物，并对其性质进行了研究。一种涉及金属而不是以配体为中心的氧化还原反应的互补方法将被研究。此外，还将实施一种新的高产率策略，以制备具有可合成可编程结构和性能的大环多金属化合物。一旦优化，这一策略应该适用于几乎任何过渡金属。本研究的目标是制备可以在小分子同时释放或吸收的情况下从一种状态电化学转换到另一种状态的金属络合物。将确定这些化合物用于分离的效用，特别是对制药工业重要的手性分子，并探索它们作为分子开关的应用。尽管不是这项研究的直接目标，但这些结果也可能导致催化剂和传感器材料的合理设计。参与这个项目的学生将接受无机和分析方法的培训，本科生的参与将通过利用西北大学现有的REU项目来实现。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Chad Mirkin of the Department of Chemistry at Northwestern University on the use of redox-active hemilabile ligands (RHLs) to control the coordination sites at transition metal centers. A series of compounds, including polyterthienyl RHL complexes of Ru, will be synthesized and their properties studied. A complimentary approach involving metal rather than ligand-centered redox reactions will be investigated. In addition, a new high yield strategy for preparing macrocyclic multimetallic compounds with synthetically programmable structures and properties will be implemented. Once optimized, this strategy should be useful for virtually any transition metal.The goal of this research is to prepare metal complexes which can be electrochemically changed from one state to another with the concurrent release or uptake of small molecules. The utility of these compounds for separations, particularly of chiral molecules important to the pharmaceutical industry, will be determined, and their application as molecular switches explored. Although not a direct objective of this research, the results could also lead to a rational design of materials for catalysts and sensors. The students involved in this project will receive training in both inorganic and analytical methodology, and undergraduate participation will be achieved by leveraging an existing REU program at Northwestern.