Supramolecular Redox-active and Inactive Systems Derived From Hemilabile Ligands

无机，生物无机和有机化学计划的这一奖项支持西北大学化学系的Chad Mirkin教授关于使用氧化还原活性半不稳定配体（RHL）控制过渡金属中心配位位点的研究。 本论文将合成一系列钌的聚三噻吩RHL配合物，并对其性质进行研究。 一个互补的方法，涉及金属，而不是配体为中心的氧化还原反应将进行调查。此外，一个新的高产率的策略，制备大环多金属化合物的合成可编程的结构和性能将实施。一旦优化，这种策略应该是有用的，几乎任何过渡金属。本研究的目标是制备金属络合物，可以电化学从一种状态到另一种状态的同时释放或吸收的小分子。 这些化合物的分离，特别是对制药工业重要的手性分子的效用，将被确定，并探讨其作为分子开关的应用。 虽然不是这项研究的直接目标，但结果也可能导致催化剂和传感器材料的合理设计。 参与该项目的学生将接受无机和分析方法的培训，本科生的参与将通过利用西北大学现有的REU计划来实现。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Chad Mirkin of the Department of Chemistry at Northwestern University on the use of redox-active hemilabile ligands (RHLs) to control the coordination sites at transition metal centers. A series of compounds, including polyterthienyl RHL complexes of Ru, will be synthesized and their properties studied. A complimentary approach involving metal rather than ligand-centered redox reactions will be investigated. In addition, a new high yield strategy for preparing macrocyclic multimetallic compounds with synthetically programmable structures and properties will be implemented. Once optimized, this strategy should be useful for virtually any transition metal.The goal of this research is to prepare metal complexes which can be electrochemically changed from one state to another with the concurrent release or uptake of small molecules. The utility of these compounds for separations, particularly of chiral molecules important to the pharmaceutical industry, will be determined, and their application as molecular switches explored. Although not a direct objective of this research, the results could also lead to a rational design of materials for catalysts and sensors. The students involved in this project will receive training in both inorganic and analytical methodology, and undergraduate participation will be achieved by leveraging an existing REU program at Northwestern.