Allosterically Regulated Supramolecular Capsules and Receptors Assembled via the WLA

通过 WLA 组装的变构调节超分子胶囊和受体

基本信息

批准号：
1709888
负责人：
Chad Mirkin
金额：
$ 59.5万
依托单位：
Northwestern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709888&HistoricalAwards=false
关键词：
Allosterically Regulated Supramolecular Capsules Receptors

项目摘要

In this project, funded by the Macromolecular, Supramolecular and Nanochemistry program, Professor Chad A. Mirkin of Northwestern University is developing design rules for the synthesis of special molecules that can serve as capsules with controllable size and recognition properties for applications in detectors, molecular separations, and catalysis. The rational design and synthesis of these capsules, is a significant challenge in the field of the assembly of supramolecular structures, could lead to significant advances related to the purification of pharmaceuticals essential in clinical medicine, the conversion of low-value to high-value chemical feedstocks important to the chemical and petroleum industries, and the development of chemical sensors critical to the environmental testing and food packaging fields. Specifically, this project focuses on the development of stimuli-responsive heterodimeric capsules, using robust and generalizable chemistry that can be implemented in a wide variety of settings. Various capsules are being synthesized and studied in the context of the Weak-Link approach, and the most promising are being characterized further using X-ray crystallography, multinuclear NMR spectroscopy, isothermal titration calorimetry, mass spectrometry, and UV-vis spectroscopy. The chemical and physical properties of these novel heterodimeric capsules are being defined through collaborative efforts with core facilities, such as the Integrated Molecular Structure Education and Research Center (IMSERC), at Northwestern University. Outreach programs aimed at engaging local high school students and undergraduates from around the world have been established by Mirkin. These programs focus on mentoring students, teaching them technical aspects of laboratory research, and preparing them for the next stage of their academic careers. These young students are learning about scientific research at the forefront of the field and interacting with leading scientists, graduate students, and postdoctoral researchers. This work provides a training ground for young students, including underrepresented minorities, and equips them with basic science knowledge essential for developing technologies that can significantly improve the lives of many Americans.

在这个项目中，由大分子，超分子和纳米化学计划资助，西北大学的Chad A. Mirkin教授正在制定设计规则，用于合成特殊分子的设计规则，这些分子可以用作具有可控尺寸和识别属性的胶囊，可用于探测器，分子分离和催化性。这些胶囊的理性设计和合成是在超分子结构组装领域的一个重大挑战，可能会导致与临床医学中必不可少的药物纯化相关的重大进展，低价值向高价值化学饲料对化学和Petroleum Industrie和Petroleum Inderties和化学传感器的开发和化学传感器的发展至关重要。具体而言，该项目的重点是使用可在各种环境中实施的稳健且可推广的化学反应的刺激反应性异含量胶囊的发展。在弱链接方法的背景下，正在合成和研究各种胶囊，使用X射线晶体学，多核NMR光谱，等热滴定热量表，质谱法和UV-VIS光谱法。这些新型异二聚体胶囊的化学和物理性能是通过与核心设施的合作努力（例如西北大学的综合分子结构教育与研究中心（IMSERC）的合作努力来定义的。米尔金（Mirkin）建立了旨在吸引当地高中生和本科生的外展计划。这些计划着重于指导学生，教给他们实验室研究的技术方面，并为他们的学术职业的下一阶段做准备。这些年轻的学生正在学习该领域最前沿的科学研究，并与领先的科学家，研究生和博士后研究人员进行互动。这项工作为包括代表性不足的少数群体在内的年轻学生提供了培训理由，并为他们提供基础科学知识，对于开发可以显着改善许多美国人生活的技术至关重要。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Multi-State Dynamic Coordination Complexes Interconverted through Counterion-Controlled Phase Transfer

通过反离子控制相转移相互转换的多态动态协调配合物

DOI：
10.1021/acs.inorgchem.0c03708
发表时间：
2021
期刊：
Inorganic Chemistry
影响因子：
4.6
作者：
Cheng, Ho Fung;Paul, McKinley K.;d’Aquino, Andrea I.;Stern, Charlotte L.;Mirkin, Chad A.
通讯作者：
Mirkin, Chad A.

A Redox-Switchable, Allosteric Coordination Complex