Stimuli-Responsive Supramolecular Assemblies

刺激响应超分子组装体

• 批准号: 1149314
• 负责人: Chad Mirkin
• 金额: $ 48万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1149314&HistoricalAwards=false
• 关键词: Stimuli; Responsive; Supramolecular; Assemblies

In this project, funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Chad A. Mirkin of Northwestern University will employ the Weak-Link Approach (WLA) to rationally design and synthesize chemically sophisticated, highly functional supramolecular architectures with important capabilities in the context of molecular recognition, catalysis, and amplified detection. The cooperative chemical properties that arise from such motifs lead to allosteric capabilities, where their activity can be regulated through small-molecule or ion-binding events at remote metal sites. These features make the WLA an ideal platform for synthesizing abiotic structures capable of mimicking and sometimes exceeding the structural and functional sophistication of biological systems. Specifically, the proposed project will explore: 1) the development of Pt(II) WLA chemistry, 2) the expansion of the scope of functionalities that can be incorporated into WLA complexes, and 3) the development of more diverse methods for inducing WLA complex conformation change. Furthering the understanding of the WLA not only will lead to the discovery of novel reactions, but also structures with unique properties that cannot be synthesized via any other methodology.This research program will impact the training and education of graduate students and postdoctoral scholars. These young scientists will gain important laboratory skills in supramolecular inorganic coordination chemistry, homogeneous catalysis, spectroscopy, and analytical chemistry. Advances will be disseminated to the scientific community through publication in high-impact journals and presentations at national and international scientific conferences, and to the general public via the popular press and through participation in outreach events like the NSF Nanoscale Informal Science Education Network (NISEnet) and NanoDays. Undergraduate students and high-school teachers will participate in the research activities of this program through summer REU and RET programs run through Northwestern University.

本项目由化学系高分子、超分子和纳米化学项目资助。西北大学的Mirkin将采用弱连接方法（WLA）来合理设计和合成化学复杂的，高功能的超分子结构，这些结构在分子识别，催化和放大检测方面具有重要的能力。由这些基序产生的协同化学性质导致变构能力，其中它们的活性可以通过在远程金属位点的小分子或离子结合事件来调节。这些特征使WLA成为合成非生物结构的理想平台，这些非生物结构能够模仿甚至超越生物系统的结构和功能复杂性。具体而言，拟议的项目将探索：1）Pt（II）WLA化学的发展，2）可纳入WLA复合物的功能范围的扩大，以及3）开发更多样化的方法来诱导WLA复合物构象变化。 进一步了解WLA不仅会发现新的反应，而且会发现具有独特性质的结构，这些结构无法通过任何其他方法合成。该研究计划将影响研究生和博士后学者的培训和教育。这些年轻的科学家将获得超分子无机配位化学，均相催化，光谱学和分析化学的重要实验室技能。这些进展将通过在高影响力期刊上发表和在国家和国际科学会议上的演讲传播给科学界，并通过大众媒体和通过参与NSF纳米尺度非正式科学教育网络（NISEnet）和NanoDays等外联活动传播给公众。 本科生和高中教师将通过西北大学的夏季REU和RET课程参与该计划的研究活动。