Metallosupramolecular Complexes Through Coordination Chemistry

通过配位化学制备金属超分子配合物

• 批准号: 0447674
• 负责人: Chad Mirkin
• 金额: $ 40.5万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0447674&HistoricalAwards=false
• 关键词: Metallosupramolecular; Complexes; Through; Coordination; Chemistry

Dr. Chad Mirkin, Chemistry Department, Northwestern University, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for the rational design of macrocyclic and higher ordered supramolecular structures. The primary objective is to develop a novel synthetic methodology, termed the "Weak-Link Approach" (WLA), for constructing supramolecular structures from symmetrical hemilabile ligands and transition metals. The WLA allows one to rationally design and prepare two- and three-dimensional molecular architectures with dimensions that are extraordinarily large. Moreover, it allows functionality to be introduced into such structures. In this project, two classes of structures are targeted: 1) macrocyclic multimetallic compounds with synthetically programmable structural, chemical, and photophysical properties with unusual host-guest chemistry, and 2) a new type of biomimetic allosteric catalyst for reactions of both synthetic and industrial relevance. Class 1 complexes will consist of ligands and metal centers that provide control over complex size, shape, water solubility, fluorescence, and chirality. Class 2 complexes will use this control to create supramolecular compounds with arrays of metal centers arranged in such a way that reactivity at a distal site will control catalytic chemistry at a catalytic site. The objectives of this proposal are to develop a novel synthetic approach to form very large structures, whose chemical and physical properties can be tailored. A major aim of these studies is to develop new types of complexes with potentially useful photochemical and catalytic properties. These may have applications in organic synthesis and as molecular sensors. Additionally, these compounds may be useful for separations, particularly of chiral molecules important to the pharmaceutical industry. The students involved in this project will receive training in both inorganic and analytical methodology, and undergraduate participation will be achieved by leveraging existing REU programs at Northwestern.

西北大学化学系的Chad Mirkin博士得到了化学部的无机，生物无机和有机金属化学计划，用于大环和高度有序的超分子结构的合理设计。主要目的是开发一种新型的合成方法，称为“弱链接方法”（WLA），用于从对称的半脂质配体和过渡金属中构建超分子结构。 WLA允许一个理性设计并制备具有极大尺寸的二维分子体系结构。此外，它允许将功能引入此类结构。在该项目中，有两类结构是针对的：1）具有合成的结构，化学和光物理特性的大环的多金属化合物，具有异常的宿主 - 宿主化学性质，以及2）一种新型的生物象征性变构催化剂，用于合成和工业相关性的反应。 1类配合物将由配体和金属中心组成，这些配体和金属中心可以控制复杂尺寸，形状，水溶性，荧光和手性。 2类配合物将使用此控件来创建超分子化合物，其阵列的金属中心阵列的排列方式使远端位点的反应性将控制催化位点的催化化学。该提案的目标是开发一种新型的合成方法来形成非常大的结构，其化学和物理特性可以量身定制。这些研究的主要目的是开发具有潜在有用的光化学和催化特性的新型复合物。这些可能在有机合成和作为分子传感器中应用。此外，这些化合物可能对分离有用，特别是对制药行业重要的手性分子。 参与该项目的学生将接受无机和分析方法的培训，并通过利用西北航空的现有REU计划来实现本科参与。