Virus-induzierte regulatorische T Zellen in retroviralen Infektionen: Neue Ziele für die Immuntherapie von chronischen Infektionen (B04)

逆转录病毒感染中病毒诱导的调节性 T 细胞：慢性感染免疫治疗的新靶点 (B04)

• 批准号: 141744079
• 金额: --
• 依托单位: Institut für Virologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/141744079?language=en
• 关键词: Virus; induzierte; regulatorische; Zellen; retroviralen

In this project the role of Tregs in chronic retroviral infection was investigated. The PIs showed that Tregs expand during the late phase of acute FV infection and subsequently suppressed cytotoxic T cell responses and contributed to the development of chronic infection. They defined several molecular pathways that are involved in the activation and expansion of Tregs. This knowledge will be used to therapeutically block Treg expansion and prevent effector T cell exhaustion. In addition, the interaction of Tregs, CTL and their virus-infected targets will be imaged in the living mouse using intravital 2-photon microscopy. Furthermore, therapeutic vaccines that can overcome Treg mediated suppression during chronic infection will be developed.

在这个项目中，我们研究了Tregs在慢性逆转录病毒感染中的作用。PI显示，Tregs在急性FV感染的晚期扩张，随后抑制细胞毒性T细胞反应，并有助于慢性感染的发展。他们定义了几条参与Tregs激活和扩张的分子途径。这一知识将被用来在治疗上阻止Treg的扩张，并防止效应器T细胞耗尽。此外，Tregs、CTL和它们的病毒感染靶标之间的相互作用将在活着的小鼠身上用活着的双光子显微镜进行成像。此外，还将开发能够克服Treg介导的慢性感染抑制的治疗性疫苗。