Modulierung spezifischer T Zellantworten gegen das Hepatitis B Virus (HBV) durch PRRs (TLR2 und -13) und PRR Detektion der HBV Infektion (B05)

该项目的重点是TLR2在乙肝病毒传感和TLR2配体驱动的乙肝病毒特异性T细胞反应中的作用。TLR2配体激活肝脏中的LSECs，促进局部T细胞对乙肝病毒的反应。由此产生的肝内T细胞反应有效地介导了小鼠模型中的乙肝病毒清除。PIS将研究TLR2介导的乙肝病毒特异性T细胞激活的分子机制，以及如何在肝脏环境中优化它们的功能和生存。这将在动物模型(小鼠、土拨鼠)和来自乙肝病毒感染者的患者样本中进行测试。他们还将分析在乙肝病毒感染期间，肉豆蔻酰化的乙肝表面抗原是否是TLR2配体操作的。将在慢性乙肝病毒感染的小鼠模型中分析乙肝表面抗原驱动的肝内Treg反应的机制。

Project focuses on the role of TLR2 in HBV sensing and TLR2 ligand driven HBV-specific T cell responses. TLR2 ligands activate LSECs in the liver to promote local T cell responses against HBV. The resultant intrahepatic T cell response efficiently mediates HBV clearance in mouse models. The PIs will investigate the molecular mechanisms underlying TLR2-mediated activation of HBV-specific T cells and how their function and survival can be optimized in the hepatic environment. This will be tested in animal models (mouse, woodchuck) and patient samples from HBV-infected individuals. They will also analyze whether myristoylated HBsAg is a TLR2 ligand operative during HBV infection. The mechanisms underlying HBsAg driven intrahepatic Treg responses, will be analyzed in mouse models of chronic HBV infection.