Data System Upgrades for Mass Spec/NMR Core Facility

质谱/核磁共振核心设施的数据系统升级

• 批准号: 0078192
• 负责人: David Bernlohr
• 金额: $ 7.58万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078192&HistoricalAwards=false
• 关键词: Data; System; Upgrades; Mass; Spec

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Minnesota in Twin Cities will acquire a data system upgrade for their Mass Spectrometer/NMR core facility. This equipment will enhance research in a number of areas including a) investigations on photosynthetic intermediates; b) metabolic regulation of the plant hormones and genomic approaches to auxin biology; c) biochemistry and chemical ecology of pine bark beetles; d) nitrogen metabolism; structure-function studies of intracellular lipid binding proteins; and e) vitamin K-dependent proteins and sulfur dioxide reactions with nitric oxide. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. Upgraded data systems will increase efficiency of the entire facility, increase educational activities and improve investigator access to instrumentation. The results from these studies will have an impact in a number of areas including biochemistry, molecular biology and biophysics, chemistry, and plant pathology.

在化学研究仪器和设施（CRIF）计划的支持下，双城明尼苏达大学化学系将为其质谱仪/NMR核心设施获得数据系统升级。这一设备将加强若干领域的研究，包括a）光合作用中间体的研究; B）植物激素的代谢调节和生长素生物学的基因组方法; c）松树小蠹的生物化学和化学生态学; d）氮代谢;细胞内脂质结合蛋白的结构-功能研究; e）维生素K依赖蛋白和二氧化硫与一氧化氮的反应。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，使用最先进的核磁共振光谱法至关重要。 升级后的数据系统将提高整个设施的效率，增加教育活动，并改善调查人员使用仪器的情况。 这些研究的结果将在生物化学、分子生物学和生物物理学、化学和植物病理学等许多领域产生影响。