Purchase and Upgrade of NMR Instrumentation for NC State University

北卡罗来纳州立大学核磁共振仪器采购及升级

• 批准号: 0078253
• 负责人: Bruce Novak
• 金额: $ 29万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078253&HistoricalAwards=false
• 关键词: Purchase; Upgrade; NMR; Instrumentation; NC

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at North Carolina State University will upgrade a 300 MHz NMR and acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) synthesis of natural products and biologically active compounds using chiral auxiliary mediated asymmetric synthesis; b) the design and use of stereoregular polymers in direct lithography schemes; c) synthesis of multiporphyrin light-harvesting arrays and related molecular photonic devices; d) polymers with well-defined architectures; e) paramagnetic ligands for novel extended solids and porphyrins as building blocks for molecule-based magnets; and f) coumarin based cyclic prodrugs of peptides and peptidomimetics. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including materials chemistry.

通过化学研究工具和设施（CRIF）计划的奖项，北卡罗来纳州立大学的化学系将升级300 MHz NMR并获得400 MHz NMR光谱仪。该设备将使研究人员能够对A）使用手性辅助介导的不对称合成的天然产物和生物活性化合物进行研究； b）直接光刻方案中的立体聚合物的设计和使用； c）多形酸缩蛋白光捕获阵列和相关分子光子器件的合成； D）具有明确定义的架构的聚合物； e）新型扩展固体和卟啉作为基于分子的磁体的基础的顺磁性配体；和f）基于香豆素的肽和肽仪的循环前药。 核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具。它用于识别未知物质，以表征分子中原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于正在进行边境研究的化学家来说，获得最先进的NMR光谱法至关重要。这些NMR研究的结果将在包括材料化学在内的许多领域产生影响。