Purchase and Upgrade of NMR Instrumentation for NC State University

凭借化学研究仪器和设施（CRIF）计划的这一奖项，北卡罗来纳州州立大学化学系将升级300 MHz NMR并获得400 MHz NMR光谱仪。该设备将使研究人员能够进行以下研究：a）利用手性辅助介导的不对称合成合成天然产物和生物活性化合物; B）在直接光刻方案中设计和使用有规立构的聚合物; c）合成多卟啉光捕获阵列和相关的分子光子器件; d）具有明确结构的聚合物; e）用于新型扩展固体的顺磁性配体和作为分子基磁体的结构单元的卟啉;和f）肽和肽模拟物的香豆素基环状前药。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果将对包括材料化学在内的许多领域产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at North Carolina State University will upgrade a 300 MHz NMR and acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) synthesis of natural products and biologically active compounds using chiral auxiliary mediated asymmetric synthesis; b) the design and use of stereoregular polymers in direct lithography schemes; c) synthesis of multiporphyrin light-harvesting arrays and related molecular photonic devices; d) polymers with well-defined architectures; e) paramagnetic ligands for novel extended solids and porphyrins as building blocks for molecule-based magnets; and f) coumarin based cyclic prodrugs of peptides and peptidomimetics. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including materials chemistry.