Purchase and Upgrade of NMR Instrumentation for NC State University

北卡罗来纳州立大学化学系将利用化学研究仪器和设施(CRIF)计划授予的这一奖项，升级一台300 MHz核磁共振，并获得一台400 MHz核磁共振光谱仪。该设备将使研究人员能够开展以下研究：a)利用手性辅助中介的不对称合成来合成天然产物和生物活性化合物；b)直接光刻方案中立体规则聚合物的设计和使用；c)多卟啉捕光阵列和相关分子光子器件的合成；d)具有明确结构的聚合物；e)新型扩展固体的顺磁性配体和作为分子磁体构建块的卟啉；以及f)基于香豆素的多肽和多肽仿制的环状前体药物。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果将对包括材料化学在内的许多领域产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at North Carolina State University will upgrade a 300 MHz NMR and acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) synthesis of natural products and biologically active compounds using chiral auxiliary mediated asymmetric synthesis; b) the design and use of stereoregular polymers in direct lithography schemes; c) synthesis of multiporphyrin light-harvesting arrays and related molecular photonic devices; d) polymers with well-defined architectures; e) paramagnetic ligands for novel extended solids and porphyrins as building blocks for molecule-based magnets; and f) coumarin based cyclic prodrugs of peptides and peptidomimetics. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including materials chemistry.