Combinatorial Surface Chemistry: Novel Approach Towards Biomimetic Sensor Development

组合表面化学：仿生传感器开发的新方法

• 批准号: 0091390
• 负责人: Roger Leblanc
• 金额: $ 36万
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0091390&HistoricalAwards=false
• 关键词: Combinatorial; Surface; Chemistry; Novel; Approach

This award to Dr. Roger Leblanc of the University of Miami is supported by the Analytical and Surface Chemsitry Program. The research focuses on the development of surfaces, based on Langmuir-Blodgett techniques, which have high specificity for target biomolecules, and would be used for sensor development. The research is multi-disciplinary and will include the areas of synthesis, interfacial chemistry and analytical chemistry (sensor development and characterization). The key qoals of the project are 1) synthesis of a lipid/organic monolayer at the water/air interface using combinatorial chemistry, 2) determine the monolayer specificity toward target biomolecules, 3) determine whether the specificity of the monolayer be enhanced by using target templates during the synthesis, and 4) use the sensor with actual biological systems. This is a novel research proposal at the frontier of biosensor development. It has a degree of risk, however, the investigator makes a concerted effort to address the potential problems. The potential for involvement of minority students is high. The impact of this research will be felt in the areas of combinatorial synthesis, biochemistry, surface chemistry and sensor development. In the future, there is potential for societal impact if sensor applications develop in biological systems.

该奖项授予迈阿密大学的Roger Leblanc博士，由分析和表面化学计划提供支持。 该研究的重点是基于Langmuir-Blodgett技术的表面开发，该技术对目标生物分子具有高度特异性，并将用于传感器开发。 该研究是多学科的，将包括合成，界面化学和分析化学（传感器开发和表征）领域。 该项目的主要目标是：1）利用组合化学在水/空气界面合成脂质/有机单分子膜; 2）确定单分子膜对目标生物分子的特异性; 3）确定在合成过程中是否可以通过使用目标模板来增强单分子膜的特异性;以及4）将传感器与实际的生物系统一起使用。这是生物传感器发展前沿的一个新的研究方案。 它具有一定程度的风险，但是，研究者会共同努力解决潜在的问题。 少数民族学生参与的潜力很大。 这项研究的影响将在组合合成，生物化学，表面化学和传感器开发领域。 在未来，如果传感器应用在生物系统中发展，则有可能产生社会影响。