Combinatorial Surface Chemistry: Novel Approach Towards Biomimetic in 2D

组合表面化学：二维仿生的新方法

• 批准号: 0416095
• 负责人: Roger Leblanc
• 金额: --
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2007-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416095&HistoricalAwards=false
• 关键词: Combinatorial; Surface; Chemistry; Novel; Approach

Professor Roger Leblanc of the University of Miami is supported by the Analytical and Surface Chemistry Program to utilize a two-dimensional combinatorial chemistry technique to produce novel bioactive surfaces. The idea is to utilize engineered peptide lipids spread at an air/water interface. In project one, it is considered that if enough combinations of these species are present, there should on average be aligned peptide sections that mimic active sites of actual enzymes. The first target is Acetylcholinesterase. In the second project, the aggregation of beta-amyloid in two dimensions will be explored. New molecules that act as beta-sheet breakers will be sought. A third project is to study peptide-capped fluorescent quantum dots as possible optical biosensors. Monolayer techniques, FTIR spectroscopy, atomic force microscopy and scanning electron microscopy will be used in the studies.This work lies in the areas of molecular recognition, signaling and biosensors. Studying amyloid protein aggregation and understanding its precise mechanism will enable rational design of beta-sheet breakers that are putative drugs for preventing Alzheimer's disease. Many of the applications of nanoparticles have been held back due to stability issues in aqueous environments, and the approaches here could serve to lengthen lifetimes and ruggedness of designed particles. In addition, underrepresented minority students are included within summer experiences at this Hispanic Serving Institute.

迈阿密大学的Roger Leblanc教授得到了分析和表面化学项目的支持，利用二维组合化学技术生产新型生物活性表面。这个想法是利用在空气/水界面上散布的工程肽脂质。 在项目一中，认为如果存在这些物质的足够组合，则平均而言应该存在模拟实际酶的活性位点的比对肽部分。 第一个目标是乙酰胆碱酯酶。 在第二个项目中，将探索β-淀粉样蛋白在两个维度上的聚集。将寻找充当β折叠破坏者的新分子。 第三个项目是研究肽覆盖的荧光量子点作为可能的光学生物传感器。 本研究将采用单分子膜技术、傅立叶变换红外光谱、原子力显微镜和扫描电子显微镜等技术，在分子识别、信号传导和生物传感器等领域进行研究。 研究淀粉样蛋白聚集并了解其精确机制将使β折叠破坏剂的合理设计成为预防阿尔茨海默病的假定药物。 由于在水环境中的稳定性问题，纳米颗粒的许多应用都受到了阻碍，这里的方法可以延长设计颗粒的寿命和耐用性。 此外，代表性不足的少数民族学生包括在这个西班牙裔服务机构的夏季经验。