MRI: Acquisition of a 400 MHz NMR Spectrometer for Research and Research Training in Chemistry at Connecticut College

MRI：采购 400 MHz NMR 波谱仪，用于康涅狄格学院化学研究和研究培训

• 批准号: 0115653
• 负责人: Bruce Branchini
• 金额: $ 27.15万
• 依托单位: Connecticut College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0115653&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Connecticut College will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) tandem intramolecular cyclization-Claisen rearrangement sequence as a facile route to the tetracyclic 5-7-6-3 ring system of phorbol; b) synthetic strategies toward the ingenol ring system; c) novel syntheses of biologically active 5,7-fused sesquiterpenoids; d) synthesis and characterization of firefly luciferin analogs; e) solution structure of the C-terminal domain of firefly luciferase; f) synthesis and characterization of doubly 15N-labeled coelenterazine; and g) the 13C-NMR characterization of nonaqueous sol-gel systems. The NMR will also be used in the undergraduate laboratory courses. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry.

康涅狄格大学化学系将从主要研究仪器(MRI)计划获得这一奖项，以获得一台400 MHz的核磁共振光谱仪。该设备将使研究人员能够开展以下方面的研究：a)串联分子内环化-Claisen重排序列，作为通向佛波醇的四环5-7-6-3环系的简便途径；b)吲哚环系的合成策略；c)生物活性5，7-稠合倍半萜类化合物的新合成；d)萤火虫荧光素类似物的合成和表征；e)萤火虫荧光素酶C末端结构域的溶液结构；f)双15N标记的Coelenterazine的合成和表征；以及g)非水溶胶-凝胶体系的13C-核磁共振表征。核磁共振也将用于本科实验室课程。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机化学产生影响。