MRI: Acquisition of a 400 MHz Solid-State NMR Spectrometer

MRI：购买 400 MHz 固态核磁共振波谱仪

• 批准号: 0116333
• 负责人: Michael Novak
• 金额: $ 38.62万
• 依托单位: Miami University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0116333&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; Solid

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Miami University in Oxford will acquire a 400 MHz solid-state nuclear magnetic resonance (NMR)spectrometer. This equipment will enable researchers to carry out studies on a) the characterization of the membrane-bound protein phospholamban; b) an investigation of the structure and mechanism of action of CREP-1; c) an examination of the metalloenzyme metallo-beta-lactamase, believed responsible for antibiotic resistance in bacteria; d) organically modified polymers and their use in combinatorial chemistry; e) influence of dendrimers on sol-gel materials; and f) development of novel packing materials for chromatographic separations. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas, in particular, medicinal chemistry, biochemistry and materials chemistry.

凭借重大研究仪器 (MRI) 计划的这一奖项，牛津迈阿密大学化学与生物化学系将购买一台 400 MHz 固态核磁共振 (NMR) 波谱仪。该设备将使研究人员能够开展以下研究：a) 膜结合蛋白受磷蛋白的表征； b) CREP-1的结构和作用机制的研究； c) 对金属酶金属-β-内酰胺酶的检查，该酶被认为是细菌抗生素耐药性的原因； d) 有机改性聚合物及其在组合化学中的用途； e) 树枝状聚合物对溶胶-凝胶材料的影响； f) 开发用于色谱分离的新型填料。 核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。这些核磁共振研究的结果将对许多领域产生影响，特别是药物化学、生物化学和材料化学。