From Seed to Seed: Genome-wide Expression Analysis of Arabidopsis throughout Its Life Cycle
From Seed to Seed: Genome-wide Expression Analysis of Arabidopsis throughout Its Life Cycle
批准号:
0117281
负责人:
John Quackenbush
金额:
$90.0万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-01 至 2004-08-31
中文摘要
拟南芥(Arabidopsis thaliana)是一种植物模式生物,已成为植物生物学家研究的重要工具。拟南芥测序的主要动机是作为其他植物基因组的参考。为了实现这一点,必须推断出大量未知和假设基因的功能,并提供拟南芥与其他植物物种基因之间的交叉参考。最终,数据资源的开发将导致对植物基因表达和功能的更好理解。预测的基因将被扩增并用于构建全基因组微阵列,该微阵列将用于观察植物生命周期中基因表达的模式。表达数据可以帮助提供基因的功能分配和用于识别代谢途径。数据将使用一套聚类和模式识别工具进行分析。许多数据库将被合并和整合,以提供一个基于网络的观点,基因表达和鉴定在拟南芥。
英文摘要
Arabidopsis thaliana is a plant model organism that has become a major research tool for plantBiologists. A primary motivation for the sequencing of Arabidopsis was that it would serve as a reference for other plant genomes. For this to be realized the functions of a large number of unknown and hypothetical genes must be deduced and a cross-reference between genes in Arabidopsis and other plant species provided. Ultimately, the development of the data resources will lead to a better understanding of gene expressions and function in plants.Predicted genes will be amplified and used to construct a whole genome microarray that will be used to look at patterns of gene express through the plant life cycle. Expressions data can help provide both functional assignments for genes and used in identifying metabolic pathways. The data will be analyzed using a suite of clustering and pattern recognition tool. A number of databases will be combined and integrated to provide a web-based view of gene expression and identification in Arabidopsis.
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会议论文
Reconstruction and Annotation of Transcribed Sequences in Plants
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The Future of Plant Databases Conference to be held September 10-11, 2001 in Rockville, MD
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