Neural mechanisms of reconsolidation blockade in humans

人类再巩固阻断的神经机制

• 批准号: 158251458
• 负责人: Professor Dr. Lars Schwabe
• 金额: --
• 依托单位: Arbeitsgruppe Allgemeine und Biologische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/158251458?language=en
• 关键词: Neural; mechanisms; reconsolidation; blockade; humans

Reconsolidation refers to the process in which a memory is rendered transiently labile after its reactivation. Recent findings suggest that the β-adrenergic antagonist Propranolol can impede the reconsolidation and thus reduce the strength of intrusive memories believed to cause the symptomatology in Posttraumatic Stress Disorder. However, the neural mechanisms mediating the blockade of emotional memory reconsolidation through Propranolol remain largely unexplored. The present study aims to close this gap. Aversive memories will be established using a fear conditioning paradigm. Seven days later, these fear memories will be reactivated and Propranolol will be administered to block reconsolidation. After another three days, the fear conditioning will be tested to investigate if Propranolol was capable of blocking the reconsolidation. Furthermore, it will be assessed whether the Propranolol effect on reconsolidation is context-specific. Dependent variables include skin conductance responses, heart rate, salivary cortisol, and neural activation changes as measured using fMRI. The results of the proposed project will shed light on the mechanisms by which “a blood pressure drug may dim bad memories” (Sci. Am., 2009).

再巩固是指记忆在重新激活后暂时变得不稳定的过程。最近的研究结果表明，β-肾上腺素能拮抗剂普萘洛尔可以阻碍再巩固，从而降低被认为是导致创伤后应激障碍的侵入性记忆的强度。然而，通过普萘洛尔介导情绪记忆再巩固阻滞的神经机制仍然在很大程度上未被探索。本研究旨在缩小这一差距。厌恶性记忆将使用恐惧条件反射范式建立。七天后，这些恐惧记忆将被重新激活，并将给予普萘洛尔以阻断再巩固。再过三天后，将测试恐惧条件反射以研究普萘洛尔是否能够阻断再巩固。此外，还将评估普萘洛尔对再巩固的影响是否具有背景特异性。因变量包括皮肤电导反应、心率、唾液皮质醇和使用功能磁共振成像测量的神经激活变化。拟议项目的结果将揭示“血压药物可能使不良记忆变暗”的机制。我是，2009年）。