Neural mechanisms of reconsolidation blockade in humans

人类再巩固阻断的神经机制

• 批准号: 158251458
• 负责人: Professor Dr. Lars Schwabe
• 金额: --
• 依托单位: Arbeitsgruppe Allgemeine und Biologische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/158251458?language=en
• 关键词: Neural; mechanisms; reconsolidation; blockade; humans

Reconsolidation refers to the process in which a memory is rendered transiently labile after its reactivation. Recent findings suggest that the β-adrenergic antagonist Propranolol can impede the reconsolidation and thus reduce the strength of intrusive memories believed to cause the symptomatology in Posttraumatic Stress Disorder. However, the neural mechanisms mediating the blockade of emotional memory reconsolidation through Propranolol remain largely unexplored. The present study aims to close this gap. Aversive memories will be established using a fear conditioning paradigm. Seven days later, these fear memories will be reactivated and Propranolol will be administered to block reconsolidation. After another three days, the fear conditioning will be tested to investigate if Propranolol was capable of blocking the reconsolidation. Furthermore, it will be assessed whether the Propranolol effect on reconsolidation is context-specific. Dependent variables include skin conductance responses, heart rate, salivary cortisol, and neural activation changes as measured using fMRI. The results of the proposed project will shed light on the mechanisms by which “a blood pressure drug may dim bad memories” (Sci. Am., 2009).

重新巩固是指记忆在重新激活后瞬间变得不稳定的过程。最近的研究结果表明，β肾上腺素能拮抗剂心得安可以阻碍创伤后应激障碍的再巩固，从而降低被认为导致创伤后应激障碍症状的侵入性记忆的强度。然而，普萘洛尔阻断情绪记忆再巩固的神经机制在很大程度上仍未被探索。本研究旨在缩小这一差距。厌恶记忆将使用恐惧条件反射范式来建立。七天后，这些恐惧记忆将被重新激活，普萘洛尔将被用来阻止再巩固。再过三天，将对恐惧条件反射进行测试，以调查心得安是否有能力阻止再巩固。此外，还将评估心得安对再合并的影响是否因具体情况而异。因变量包括皮肤电导反应、心率、唾液皮质醇和使用fMRI测量的神经激活变化。这项拟议的项目的结果将阐明“一种降压药可以模糊糟糕记忆”的机制(科学。上午，2009)。