Stress and the retrieval of transformed memories: temporal dynamics and neuronal correlates

压力和转换记忆的检索：时间动态和神经相关性

• 批准号: 274007358
• 负责人: Professor Dr. Lars Schwabe
• 金额: --
• 依托单位: Arbeitsbereich Kognitionspsychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/274007358?language=en
• 关键词: Stress; retrieval; transformed; memories; temporal

Stress may hamper memory retrieval. This impairing effect of stress is mainly mediated by the hippocampus. Popular memory models assume that the role of the hippocampus in memory retrieval decreases over time or that retrieval becomes even independent of the hippocampus, thus raising the question whether the retrieval of remote memories is not or at least less affected by stress than the retrieval of recent memories. This question is of particular importance for the understanding of stress effects on memory processes and may also have relevant clinical implications because novel treatment approaches attempt to employ the disruptive effects of stress (hormones) to reduce dysfunctional memories in several psychiatric disorders. Therefore, the present study examines the influence of psychosocial stress (Trier Sociat Stress Test) on the retrieval of recent and remote memories as well as the underlying brain processes using functional magnetic resonance imaging. The findings of this project may have important implications for clinical applications of the stress-induced retrieval impairment. Moreover, this project will provide novel, important insights into human memory, in particular with respect to the role of the hippocampus for memory retrieval and memory transformation processes over time.

压力可能会阻碍记忆的恢复。这种应激损伤效应主要是由海马体介导的。流行的记忆模型假设海马体在记忆提取中的作用随着时间的推移而减少，或者提取甚至变得独立于海马体，从而提出了这样一个问题：远端记忆的提取是否没有或至少比最近记忆的提取受到压力的影响更小。这个问题对于理解压力对记忆过程的影响特别重要，也可能具有相关的临床意义，因为新的治疗方法试图利用压力(激素)的破坏性效应来减少几种精神障碍的功能障碍记忆。因此，本研究使用功能磁共振成像技术研究了心理社会压力(Trier Social Stress Test)对最近和遥远记忆的提取以及潜在的大脑过程的影响。本课题的研究结果可能对应激性提取障碍的临床应用具有重要的指导意义。此外，该项目将为人类记忆提供新的、重要的见解，特别是关于海马体在记忆检索和记忆转换过程中的作用。