Noradrenergic arousal and systems consolidation: maintaining memory specificity?

去甲肾上腺素能唤醒和系统整合：保持记忆特异性？

• 批准号: 403479502
• 负责人: Professor Dr. Lars Schwabe
• 金额: --
• 依托单位: Centre for Cognitive Neuroimaging
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/403479502?language=en
• 关键词: Noradrenergic; arousal; systems; consolidation; maintaining

With time, memory is thought to undergo a neural reorganization, referred to as systems consolidation, during which memories are, at least partly, transferred from hippocampus to neocortical networks. This systems consolidation is highly dynamic and accompanied by a transformation from detailed, specific to more semantic, gist-like memory. Whether systems consolidation can be modulated is largely unknown. Emotional arousal-induced noradrenaline is known to be a powerful modulator of initial memory formation, leading via increased amygdala activity to increased memory strength and vividness as well as to enhanced hippocampal involvement in memory. Although it is well-established that noradrenaline may strengthen the initial consolidation of memory, its impact on systems consolidation processes and the time-dependent change in the specificity of memory is largely unknown. Based on recent rodent data, we hypothesize that post-encoding noradrenergic stimulation may change systems consolidation processes and maintain remote memories hippocampus dependent and specific. To test this hypothesis, healthy participants will be administered a placebo or the α2-adrenoceptor antagonist yohimbine, leading to increased noradrenergic stimulation, after they encode a series of neutral and emotionally arousing pictures. Memory will be tested in a recognition test, either 1 day or 28 days after encoding. To assess memory specificity, the recognition test will include, in addition to old and entirely novel items, lures carrying the gist of the initially encoded pictures as well as perceptually similar lures carrying a different gist. In order to assess the postulated systems consolidation and the neural underpinnings of post-encoding noradrenergic arousal on memory transformation, participants will be scanned with functional magnetic resonance imaging at 3T both during encoding and retention testing. Beyond their crucial relevance for our understanding of human memory in general and the long-term vividness of emotional memory in particular, the findings of this project might have implications for mental disorders in which aberrant emotional memory processing is prominent.

随着时间的流逝，记忆被认为会经历神经重组，称为系统整合，在此期间，至少部分地将记忆从海马转移到新皮层网络。该系统整合是高度动态的，并且通过从详细的，特定于更语义，类似于要点的内存的转换来完成。是否可以调制系统合并是否在很大程度上未知。人们已知情绪唤醒诱导的去甲肾上腺素是一种强大的功能，尽管甲肾上腺素可以增强记忆的初始巩固，其对系统巩固过程的影响以及记忆特异性的时间依赖性变化是未知的。根据最近的啮齿动物数据，我们假设编码后的甲肾上腺素能模拟可能会改变系统的整合过程，并保持偏远的海马依赖性和特定。为了检验这一假设，健康参与者将被安慰剂或α2-肾上腺素受体拮抗剂Yohimbine施用，从而在编码一系列中性和情感上引起的图片后，导致去甲肾上腺素能模拟增加。编码后1天或28天，将在识别测试中测试内存。为了评估记忆特异性，识别测试除了旧的和完全新颖的物品外，还包括携带最初编码图片的要旨以及具有不同要旨的诱饵。为了评估在记忆转化时编码后的诺拉尼唤醒后的假定系统合并和神经基础，参与者将在编码和保留测试期间在3T处扫描参与者的功能磁共振成像。除了我们对人类记忆的理解以及尤其是情感记忆的长期生动性的关键意义外，该项目的发现可能对精神障碍有影响，在这些精神障碍中，异常情绪记忆处理是突出的。