Influence of stress on probabilistic classification learning and the involved brain systems: What is the role of the mineralocorticoid receptor?

压力对概率分类学习和相关大脑系统的影响：盐皮质激素受体的作用是什么？

• 批准号: 163456524
• 负责人: Professor Dr. Lars Schwabe
• 金额: --
• 依托单位: Abteilung für Neurologische Traumatologie und Neurorehabilitation
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/163456524?language=en
• 关键词: Influence; stress; probabilistic; classification; learning

Probabilistic classification learning (PCL) can be controlled by a declarative system that is supported by the medial temporal lobe or by a procedural system that is based on the neostriatum. Which of the two systems controls behavior is critical for the flexibility of the acquired knowledge: the declarative but not the procedural system is associated with the acquisition of flexible knowledge. The applicants could show previously that stress before PCL modulates the engagement of multiple memory systems in favor of the procedural system. Using a combination of functional magnetic resonance imaging and a pharmacological approach, the present project aims to examine the neuroendocrine mechanism that is underlying the stress-induced shift between memory systems. In particular, the role of the mineralocorticoid receptor in this effect will be investigated. It is hypothesized that the pharmacological blockade of the mineralocorticoid receptor prevents the stress-induced bias towards procedural learning. In addition to its relevance for basic science, the planned project may have important implications for clinical and educational settings.

概率分类学习(PCL)可以由内侧颞叶支持的陈述性系统或基于新纹状体的程序性系统控制。这两个系统中的哪一个控制行为对于获得的知识的灵活性至关重要：陈述性的而不是程序性的系统与灵活的知识的获得有关。申请者先前可以证明，PCL之前的应激调节了多个记忆系统的参与，有利于程序性系统。利用功能磁共振成像和药理学方法相结合的方法，本项目旨在研究压力诱导记忆系统之间转换的神经内分泌机制。特别是，将研究盐皮质激素受体在这一效应中的作用。据推测，盐皮质激素受体的药理阻断可以阻止应激诱导的程序性学习偏差。除了与基础科学的相关性外，计划中的项目还可能对临床和教育环境产生重要影响。

项目成果

Timing matters: Temporal dynamics of stress effects on memory retrieval

• DOI: 10.3758/s13415-014-0256-0
• 发表时间: 2014-09-01
• 期刊: COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
• 影响因子: 2.9
• 作者: Schwabe, Lars;Wolf, Oliver T.
• 通讯作者: Wolf, Oliver T.

Stress Modulates the Engagement of Multiple Memory Systems in Classification Learning

• DOI: 10.1523/jneurosci.1484-12.2012
• 发表时间: 2012-08
• 期刊: The Journal of Neuroscience
• 作者: L. Schwabe;O. Wolf

Stress-induced enhancement of response inhibition depends on mineralocorticoid receptor activation

• DOI: 10.1016/j.psyneuen.2013.05.001
• 发表时间: 2013-10-01
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Schwabe, Lars;Hoeffken, Oliver;Wolf, Oliver T.
• 通讯作者: Wolf, Oliver T.

Sex differences in stress effects on response and spatial memory formation

• DOI: 10.1016/j.nlm.2013.11.020
• 发表时间: 2014-03-01
• 期刊: NEUROBIOLOGY OF LEARNING AND MEMORY
• 影响因子: 2.7
• 作者: Guenzel, Friederike M.;Wolf, Oliver T.;Schwabe, Lars
• 通讯作者: Schwabe, Lars

Mineralocorticoid Receptor Blockade Prevents Stress-Induced Modulation of Multiple Memory Systems in the Human Brain

• DOI: 10.1016/j.biopsych.2013.06.001
• 发表时间: 2013-12-01
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Schwabe, Lars;Tegenthoff, Martin;Wolf, Oliver T.
• 通讯作者: Wolf, Oliver T.