Influence of stress on probabilistic classification learning and the involved brain systems: What is the role of the mineralocorticoid receptor?

点击翻译按钮获取中文摘要

Probabilistic classification learning (PCL) can be controlled by a declarative system that is supported by the medial temporal lobe or by a procedural system that is based on the neostriatum. Which of the two systems controls behavior is critical for the flexibility of the acquired knowledge: the declarative but not the procedural system is associated with the acquisition of flexible knowledge. The applicants could show previously that stress before PCL modulates the engagement of multiple memory systems in favor of the procedural system. Using a combination of functional magnetic resonance imaging and a pharmacological approach, the present project aims to examine the neuroendocrine mechanism that is underlying the stress-induced shift between memory systems. In particular, the role of the mineralocorticoid receptor in this effect will be investigated. It is hypothesized that the pharmacological blockade of the mineralocorticoid receptor prevents the stress-induced bias towards procedural learning. In addition to its relevance for basic science, the planned project may have important implications for clinical and educational settings.