Acquisition of a Small Molecule X-Ray Facility for the Department of Chemistry at Johns Hopkins University

为约翰·霍普金斯大学化学系购置小分子 X 射线设备

• 批准号: 0215963
• 负责人: Kenneth Karlin
• 金额: $ 24.63万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0215963&HistoricalAwards=false
• 关键词: Acquisition; Small; Molecule; Ray; Facility

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Johns Hopkins University will acquire a X-ray diffractometer with CCD detector and low temperature capabilities for small molecule diffractometry. This equipment will enhance research in a number of areas including the following: a) bioinorganic modeling of metalloenzyme active sites; b) environmental inorganic chemistry and the development of copper mediated dehalogenation; c) synthesis, characterization and reactivity of aza-substituted corrole macrocycles; d) new metal-carbonyl diimine compounds of photochemical interest; e) photoinduced electron, energy, and atom transfer processes; and f) X-ray studies of metal-organic complexes for asymmetric catalysis. Faculty members from Morgan State University, Loyola College, Towson University, the University of Maryland in Baltimore County, the US Naval Academy and Gettysburg College will also have access to this equipment. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, including environmental chemistry, preparation of more efficient catalysts, and biochemistry.

在主要研究仪器（MRI）项目的支持下，约翰霍普金斯大学化学系将获得一台带有CCD探测器和低温能力的x射线衍射仪，用于小分子衍射。该设备将加强在以下几个领域的研究：a)金属酶活性位点的生物无机建模；B)环境无机化学与铜介导脱卤研究进展；C)氮杂取代氯大环的合成、表征及反应性；D)具有光化学意义的新型金属羰基二亚胺化合物；E)光致电子、能量和原子转移过程；f)金属-有机配合物不对称催化的x射线研究。来自摩根州立大学、洛约拉学院、陶森大学、巴尔的摩马里兰大学、美国海军学院和葛底斯堡学院的教职员工也将使用该设备。x射线衍射仪可以精确测量分子的完整三维结构，包括键的距离和角度，并提供分子相对于邻近分子的空间排列的准确信息。这些研究将在许多领域产生影响，包括环境化学、制备更有效的催化剂和生物化学。